PMID- 15935583
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20131121
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 153
IP  - 1
DP  - 2005 Oct 4
TI  - Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in 
      rat kidneys.
PG  - 53-7
AB  - The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 
      2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and 
      female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 
      days. Group A (control group) was fed a normal diet, Group B was fed 50 ppm 2,4-D 
      in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 
      ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of 
      drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high 
      performance liquid chromatography (HPLC). It was observed that at low doses of 
      2,4-D, the metabolite, 2,4-DCP found in the kidneys.
FAU - Aydin, Handan
AU  - Aydin H
AD  - University Istanbul, Faculty of Veterinary Medicine, Department of Pharmacology 
      and Toxicology, 34310 Avcilar, Istanbul, Turkey. haydin@istanbul.edu.tr
FAU - Ozdemir, Nurullah
AU  - Ozdemir N
FAU - Uzunoren, Nuray
AU  - Uzunoren N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Anthelmintics)
RN  - 0 (Chlorophenols)
RN  - 0 (Herbicides)
RN  - 059QF0KO0R (Water)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/administration & dosage/*analysis
MH  - Animal Feed
MH  - Animals
MH  - Anthelmintics/analysis
MH  - Chlorophenols/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Forensic Medicine
MH  - Herbicides/administration & dosage/*analysis
MH  - Kidney/*chemistry
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Water/chemistry
EDAT- 2005/06/07 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/07 09:00
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0379-0738(05)00206-9 [pii]
AID - 10.1016/j.forsciint.2005.04.018 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2005 Oct 4;153(1):53-7. doi: 10.1016/j.forsciint.2005.04.018.