PMID- 15935892
OWN - NLM
STAT- MEDLINE
DCOM- 20051212
LR  - 20050606
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 5
DP  - 2005 May
TI  - Elucidation of exon 1, 4, and 5 sequences of 39 infrequent HLA-B alleles.
PG  - 543-53
AB  - More than 590 human leukocyte antigen (HLA)-B alleles have been identified by 
      sequence analysis. Although the polymorphic exon 2 and 3 sequences of all HLA-B 
      alleles are described, the sequences of the other exons of a number of infrequent 
      B-alleles are unknown. In this study, the exon 1, 4, and 5 sequences of 39 
      different HLA-B alleles were elucidated by allele-specific sequencing. Overall, 
      these exon sequences showed identity with the majority of the known sequences 
      from the corresponding allele groups, except for four alleles B*4010, B*4415, 
      B*4416, and B*5606. The exon 1 sequence of B*4010 had nucleotide differences with 
      all B*40 alleles, but was identical to the B*54, *55, *56, and *59 allele groups. 
      B*4416 differed from B*440201 at position 988, which was previously considered a 
      conserved position. B*4415 showed exon 1, 4, and 5 sequences deviating from the 
      other B*44 alleles, but identical to B*4501. The exon 1 and 4 sequences of B*5606 
      differed from other B*56 alleles, but were in complete agreement with B*7801. The 
      deviating exon sequences of B*4415 and B*5606 confirmed the evolutionary origin 
      of these alleles suggested by the sequences of exons 2 and 3. The polymorphism 
      observed in exons 1, 4, and 5 merely reflects the lineage-specificity of HLA-B.
FAU - Swelsen, Wendy T N
AU  - Swelsen WT
AD  - Tissue Typing Laboratory, University Hospital Maastricht, Maastricht, The 
      Netherlands.
FAU - Voorter, Christina E M
AU  - Voorter CE
FAU - Chak, Kang Yuen
AU  - Chak KY
FAU - van den Berg-Loonen, Ella M
AU  - van den Berg-Loonen EM
LA  - eng
SI  - GENBANK/AJ850138
SI  - GENBANK/AJ850139
SI  - GENBANK/AJ850140
SI  - GENBANK/AJ850141
SI  - GENBANK/AJ850142
SI  - GENBANK/AJ850143
SI  - GENBANK/AJ850144
SI  - GENBANK/AJ850145
SI  - GENBANK/AJ850146
SI  - GENBANK/AJ850147
SI  - GENBANK/AJ850148
SI  - GENBANK/AJ850149
SI  - GENBANK/AJ850150
SI  - GENBANK/AJ850151
SI  - GENBANK/AJ850152
SI  - GENBANK/AJ850153
SI  - GENBANK/AJ850154
SI  - GENBANK/AJ850155
SI  - GENBANK/AJ850156
SI  - GENBANK/AJ850157
SI  - GENBANK/AJ850158
SI  - GENBANK/AJ850159
SI  - GENBANK/AJ850160
SI  - GENBANK/AJ850161
SI  - GENBANK/AJ850162
SI  - GENBANK/AJ850163
SI  - GENBANK/AJ850164
SI  - GENBANK/AJ850165
SI  - GENBANK/AJ850166
SI  - GENBANK/AJ850167
SI  - GENBANK/AJ850168
SI  - GENBANK/AJ850169
SI  - GENBANK/AJ850170
SI  - GENBANK/AJ850171
SI  - GENBANK/AJ850172
SI  - GENBANK/AJ850173
SI  - GENBANK/AJ850174
SI  - GENBANK/AJ850175
SI  - GENBANK/AJ850176
SI  - GENBANK/AJ850177
SI  - GENBANK/AJ850178
SI  - GENBANK/AJ850179
SI  - GENBANK/AJ850180
SI  - GENBANK/AJ850181
SI  - GENBANK/AJ850182
SI  - GENBANK/AJ850183
SI  - GENBANK/AJ850184
SI  - GENBANK/AJ850185
SI  - GENBANK/AJ850186
SI  - GENBANK/AJ850187
SI  - GENBANK/AJ850188
SI  - GENBANK/AJ850189
SI  - GENBANK/AJ850190
SI  - GENBANK/AJ850191
SI  - GENBANK/AJ850192
SI  - GENBANK/AJ850193
SI  - GENBANK/AJ850194
SI  - GENBANK/AJ850195
SI  - GENBANK/AJ850196
SI  - GENBANK/AJ850197
SI  - GENBANK/AJ850198
PT  - Journal Article
DEP - 20050219
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Alleles
MH  - Base Sequence
MH  - Exons/*genetics
MH  - Gene Conversion/genetics/immunology
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Point Mutation/genetics/immunology
MH  - Sequence Alignment
MH  - Sequence Homology, Nucleic Acid
EDAT- 2005/06/07 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/06/07 09:00
PHST- 2004/10/26 00:00 [received]
PHST- 2004/12/22 00:00 [revised]
PHST- 2005/01/03 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0198-8859(05)00015-7 [pii]
AID - 10.1016/j.humimm.2005.01.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 May;66(5):543-53. doi: 10.1016/j.humimm.2005.01.006. Epub 2005 
      Feb 19.