PMID- 15935894
OWN - NLM
STAT- MEDLINE
DCOM- 20051212
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 5
DP  - 2005 May
TI  - Inferred HLA haplotype information for donors from hematopoietic stem cells donor 
      registries.
PG  - 563-70
AB  - Human leukocyte antigen (HLA) matching remains a key issue in the outcome of 
      transplantation. In hematopoietic stem cell transplantation with unrelated 
      donors, the matching for compatible donors is based on the HLA phenotype 
      information. In familial transplantation, the matching is achieved at the 
      haplotype level because donor and recipient share the block-transmitted major 
      histocompatibility complex region. We present a statistical method based on the 
      HLA haplotype inference to refine the HLA information available in an unrelated 
      situation. We implement a systematic statistical inference of the haplotype 
      combinations at the individual level. It computes the most likely haplotype pair 
      given the phenotype and its probability. The method is validated on 301 
      phase-known phenotypes from CEPH families (Centre d'Etude du Polymorphisme 
      Humain). The method is further applied to 85,933 HLA-A B DR typed unrelated 
      donors from the French Registry of hematopoietic stem cells donors (France Greffe 
      de Moelle). The average value of prediction probability is 0.761 (SD 0.199) 
      ranging from 0.26 to 1. Correlations between phenotype characteristics and 
      predictions are also given. Homozygosity (OR = 2.08; [2.02-2.14] p <10(-3)) and 
      linkage disequilibrium (p <10(-3)) are the major factors influencing the quality 
      of prediction. Limits and relevance of the method are related to limits of 
      haplotype estimation. Relevance of the method is discussed in the context of HLA 
      matching refinement.
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
AD  - Faculty of Medicine, INSERM, Toulouse, France. gourraud@cict.fr
FAU - Lamiraux, Phillipe
AU  - Lamiraux P
FAU - El-Kadhi, Nabil
AU  - El-Kadhi N
FAU - Raffoux, Colette
AU  - Raffoux C
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050303
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Algorithms
MH  - France
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Hematopoietic Stem Cells/*immunology
MH  - Homozygote
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Models, Genetic
MH  - *Models, Statistical
MH  - Phenotype
MH  - *Registries
MH  - *Tissue Donors
EDAT- 2005/06/07 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/06/07 09:00
PHST- 2004/12/10 00:00 [received]
PHST- 2005/01/03 00:00 [revised]
PHST- 2005/01/11 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0198-8859(05)00023-6 [pii]
AID - 10.1016/j.humimm.2005.01.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 May;66(5):563-70. doi: 10.1016/j.humimm.2005.01.011. Epub 2005 
      Mar 3.