PMID- 15936109
OWN - NLM
STAT- MEDLINE
DCOM- 20060120
LR  - 20181201
IS  - 0168-3659 (Print)
IS  - 0168-3659 (Linking)
VI  - 106
IP  - 1-2
DP  - 2005 Aug 18
TI  - Drug release characteristics of multi-reservoir type microspheres with 
      poly(dl-lactide-co-glycolide) and poly(dl-lactide).
PG  - 172-80
AB  - For the multi-reservoir type microspheres composed of 
      poly(dl-lactide-co-glycolide) (PLGA) and poly(dl-lactide) (PLA), the influence of 
      the drug-holding layer and the non-drug-holding layer on drug release profiles 
      was studied. The microspheres with the blend of PLGA and PLA were prepared by the 
      W/O type emulsion-solvent evaporation technique, and cisplatin was used as a 
      model drug. The degree of water uptake and the erosion of each polymer were 
      evaluated to clarify the mechanism of drug release for multi-reservoir type 
      microspheres. The blending of PLA and PLGA provided two types of microspheres in 
      terms of the drug distribution in a microsphere, depending on the ratio of the 
      blend: the microspheres with the drug-holding layer covered by the non-drug layer 
      and the microspheres with the drug on the outer region. The drug release in the 
      early period was governed by the pattern of drug distribution. The drug release 
      rate at a steady state was governed by the erosion of the drug-holding layer. The 
      results of present study indicate that drug release from multi-reservoir type 
      microspheres involves the following process: (a) rapid release of the drug near 
      the surface of microspheres, (b) formation of micropores in the non-drug-holding 
      layer by hydration and erosion, (c) degradation of the drug-holding layer, and 
      (d) diffusion of the drug through micropores.
FAU - Matsumoto, Akihiro
AU  - Matsumoto A
AD  - Pharmaceutical Development Laboratory, Tanabe Seiyaku Co., Ltd. 16-89, Kashima 
      3-chome, Yodogawa-ku, Osaka 532-8505, Japan. pinebook@tanabe.co.jp
FAU - Matsukawa, Yasuhisa
AU  - Matsukawa Y
FAU - Suzuki, Takehiko
AU  - Suzuki T
FAU - Yoshino, Hiroyuki
AU  - Yoshino H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 059QF0KO0R (Water)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Agents/*chemistry
MH  - Cisplatin/*chemistry
MH  - Drug Carriers
MH  - Lactic Acid/*chemistry
MH  - *Microspheres
MH  - Polyesters/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Water/chemistry
EDAT- 2005/06/07 09:00
MHDA- 2006/01/21 09:00
CRDT- 2005/06/07 09:00
PHST- 2004/11/04 00:00 [received]
PHST- 2005/03/28 00:00 [revised]
PHST- 2005/03/28 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2006/01/21 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0168-3659(05)00187-2 [pii]
AID - 10.1016/j.jconrel.2005.03.026 [doi]
PST - ppublish
SO  - J Control Release. 2005 Aug 18;106(1-2):172-80. doi: 
      10.1016/j.jconrel.2005.03.026.