PMID- 15936272
OWN - NLM
STAT- MEDLINE
DCOM- 20050929
LR  - 20220129
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 15
IP  - 11
DP  - 2005 Jun 7
TI  - Pathogen-driven selection and worldwide HLA class I diversity.
PG  - 1022-7
AB  - The human leukocyte antigen (HLA; known as MHC in other vertebrates) plays a 
      central role in the recognition and presentation of antigens to the immune system 
      and represents the most polymorphic gene cluster in the human genome [1]. 
      Pathogen-driven balancing selection (PDBS) has been previously hypothesized to 
      explain the remarkable polymorphism in the HLA complex, but there is, as yet, no 
      direct support for this hypothesis [2 and 3]. A straightforward prediction coming 
      out of the PDBS hypothesis is that populations from areas with high pathogen 
      diversity should have increased HLA diversity in relation to their average 
      genomic diversity. We tested this prediction by using HLA class I genetic 
      diversity from 61 human populations. Our results show that human colonization 
      history explains a substantial proportion of HLA genetic diversity worldwide. 
      However, between-population variation at the HLA class I genes is also positively 
      correlated with local pathogen richness (notably for the HLA B gene), thus 
      providing support for the PDBS hypothesis. The proportion of variations explained 
      by pathogen richness is higher for the HLA B gene than for the HLA A and HLA C 
      genes. This is in good agreement with both previous immunological and genetic 
      data suggesting that HLA B could be under a higher selective pressure from 
      pathogens.
FAU - Prugnolle, Franck
AU  - Prugnolle F
AD  - Theoretical and Molecular Population Genetics Group, Department of Genetics, 
      University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom. 
      prugnolle@yahoo.fr
FAU - Manica, Andrea
AU  - Manica A
FAU - Charpentier, Marie
AU  - Charpentier M
FAU - Guegan, Jean Francois
AU  - Guegan JF
FAU - Guernier, Vanina
AU  - Guernier V
FAU - Balloux, Francois
AU  - Balloux F
LA  - eng
GR  - BB/C007123/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
SB  - IM
MH  - Communicable Diseases/*genetics/microbiology/parasitology/virology
MH  - Databases, Factual
MH  - Genes, MHC Class I/*genetics
MH  - *Genetic Variation
MH  - *Genetics, Population
MH  - Geography
MH  - Host-Parasite Interactions/genetics
MH  - Humans
MH  - *Models, Genetic
MH  - Population Dynamics
MH  - Regression Analysis
MH  - *Selection, Genetic
MH  - Species Specificity
EDAT- 2005/06/07 09:00
MHDA- 2005/09/30 09:00
CRDT- 2005/06/07 09:00
PHST- 2005/02/04 00:00 [received]
PHST- 2005/04/20 00:00 [revised]
PHST- 2005/04/21 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/09/30 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0960-9822(05)00451-3 [pii]
AID - 10.1016/j.cub.2005.04.050 [doi]
PST - ppublish
SO  - Curr Biol. 2005 Jun 7;15(11):1022-7. doi: 10.1016/j.cub.2005.04.050.