PMID- 1593654
OWN - NLM
STAT- MEDLINE
DCOM- 19920626
LR  - 20190509
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 84
IP  - 11
DP  - 1992 Jun 3
TI  - Case-control study of factors associated with human T-cell leukemia virus type I 
      infection in southern Miyazaki, Japan.
PG  - 867-72
AB  - BACKGROUND: An unusual age- and sex-specific distribution and a remarkably 
      restricted geographic seroprevalence characterize human T-cell leukemia virus 
      type I (HTLV-I) infection. Although the transmission routes of HTLV-I are known, 
      these seroepidemiologic features cannot be fully explained. PURPOSE: This study 
      was designed to identify potential characteristics associated with HTLV-I 
      infection in a highly endemic Japanese community. METHODS: We evaluated 
      occupational, residential, dietary, and medical histories in a case-control study 
      conducted in two neighboring villages in southeastern Miyazaki Prefecture. One 
      hundred forty-four case subjects and 276 control subjects, frequency matched by 
      age, sex, and village, were interviewed. Village-specific profiles of demographic 
      determinants of HTLV-I seroprevalence were generated using multiple logistic 
      regression. RESULTS: Although a different pattern of factors was found for each 
      village, occupations of the subjects and their fathers were associated with 
      HTLV-I infection in both communities--farming in village A and fishing and 
      farming in village B. For village A, there was more than a twofold association 
      both with residence in the township for 55 years or more and with living in a 
      particular area within the village. In addition, case subjects were more likely 
      to have a mother who was deceased (odds ratio = 1.7; 95% confidence interval = 
      0.96-2.9). CONCLUSIONS: HTLV-I infection is characterized by a high degree of 
      microepidemicity in this population, with seroprevalence related to both 
      sociologic and geographic determinants. Moreover, as carriers' mothers themselves 
      have a higher probability of being HTLV-I positive, an increased mortality among 
      those infected with the virus is suggested.
FAU - Stuver, S O
AU  - Stuver SO
AD  - Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
FAU - Tachibana, N
AU  - Tachibana N
FAU - Mueller, N
AU  - Mueller N
LA  - eng
GR  - 1 T32 ES07069/ES/NIEHS NIH HHS/United States
GR  - CA-38450/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Demography
MH  - Diet
MH  - Female
MH  - HTLV-I Infections/diagnosis/*epidemiology/etiology
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Occupations
MH  - Prevalence
MH  - Regression Analysis
MH  - Rural Population
MH  - Serologic Tests
EDAT- 1992/06/03 00:00
MHDA- 1992/06/03 00:01
CRDT- 1992/06/03 00:00
PHST- 1992/06/03 00:00 [pubmed]
PHST- 1992/06/03 00:01 [medline]
PHST- 1992/06/03 00:00 [entrez]
AID - 10.1093/jnci/84.11.867 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 1992 Jun 3;84(11):867-72. doi: 10.1093/jnci/84.11.867.