PMID- 15936612
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20151119
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 45
IP  - 11
DP  - 2005 Jun 7
TI  - Diagnostic performance of cardiovascular magnetic resonance in patients with 
      suspected acute myocarditis: comparison of different approaches.
PG  - 1815-22
AB  - OBJECTIVES: The aim of this research was to identify the diagnostic performance 
      of gadolinium-enhanced and T2-weighted cardiovascular magnetic resonance (CMR) in 
      suspected acute myocarditis. BACKGROUND: Acute myocarditis is difficult to 
      diagnose; CMR provides various means to visualize myocardial inflammatory 
      changes. A CMR approach with clear-cut diagnostic criteria would be desirable. 
      METHODS: We investigated 25 patients with suspected acute myocarditis (18 males, 
      44 +/- 17 years) and 23 healthy controls (13 males, 29 +/- 10 years). 
      Cardiovascular magnetic resonance studies included the following sequences: 1) 
      T2-weighted triple inversion recovery; 2) T1-weighted spin echo before and over 4 
      min after gadolinium injection; and 3) inversion recovery-gradient echo 10 min 
      after gadolinium injection. Qualitative and quantitative image analysis was 
      performed for: 1) focal and global T2 signal intensity (SI); 2) myocardial global 
      relative enhancement (gRE); and 3) areas of late gadolinium enhancement (LGE). 
      RESULTS: Both global T2 SI and gRE were higher in patients than in controls (T2: 
      2.3 +/- 0.4 vs. 1.7 +/- 0.4; p < 0.0001, gRE: 6.8 +/- 4.0 vs. 3.7 +/- 2.3; p < 
      0.001). The sensitivity, specificity, and diagnostic accuracy for T2 (cutoff 
      value of 1.9) were 84%, 74%, and 79%, respectively; gRE: (cutoff value of 4.0) 
      80%, 68%, and 74.5% respectively; LGE: 44%, 100%, and 71%, respectively. The best 
      diagnostic performance was obtained when "any-two" of the three sequences were 
      positive in the same patient yielding a 76% sensitivity, 95.5% specificity, and 
      85% diagnostic accuracy. CONCLUSIONS: A combined CMR approach using T2-weighted 
      imaging, early and late gadolinium enhancement, provides a high diagnostic 
      accuracy and is a useful tool in the diagnosis and assessment of patients with 
      suspected acute myocarditis.
FAU - Abdel-Aty, Hassan
AU  - Abdel-Aty H
AD  - Franz-Volhard-Klinik, Charite Campus Buch, Universitat Medizin Berlin, Berlin, 
      Germany.
FAU - Boye, Philipp
AU  - Boye P
FAU - Zagrosek, Anja
AU  - Zagrosek A
FAU - Wassmuth, Ralf
AU  - Wassmuth R
FAU - Kumar, Andreas
AU  - Kumar A
FAU - Messroghli, Daniel
AU  - Messroghli D
FAU - Bock, Petra
AU  - Bock P
FAU - Dietz, Rainer
AU  - Dietz R
FAU - Friedrich, Matthias G
AU  - Friedrich MG
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - J Am Coll Cardiol. 2005 Jun 7;45(11):1823-5. PMID: 15936613
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Image Enhancement
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnosis
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2005/06/07 09:00
MHDA- 2005/06/25 09:00
CRDT- 2005/06/07 09:00
PHST- 2004/09/01 00:00 [received]
PHST- 2004/11/03 00:00 [revised]
PHST- 2004/11/11 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0735-1097(05)00527-9 [pii]
AID - 10.1016/j.jacc.2004.11.069 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2005 Jun 7;45(11):1815-22. doi: 10.1016/j.jacc.2004.11.069.