PMID- 15936834
OWN - NLM
STAT- MEDLINE
DCOM- 20051207
LR  - 20131121
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 163
IP  - 1
DP  - 2005 Aug 30
TI  - Dopamine modulates male sexual behavior in Japanese quail in part via actions on 
      noradrenergic receptors.
PG  - 42-57
AB  - In rats, dopamine (DA) facilitates male sexual behavior through its combined 
      action on D1- and D2-like receptors, in the medial preoptic area (MPOA) as well 
      as other brain areas. In Japanese quail, systemic injections of dopaminergic 
      drugs suggested a similar pharmacology but central injections have never been 
      performed. Recent electrophysiological experiments demonstrated that DA effects 
      in the MPOA of quail are mediated mainly through the activation of 
      alpha2-noradrenergic receptors. Previous studies of DA action on behavior used 
      specific dopaminergic agonists/antagonists and therefore unintentionally avoided 
      the potential cross-reaction with alpha2-receptors. The present study was thus 
      designed to investigate directly the effects of DA on male sexual behavior and to 
      test whether the interaction of DA with heterologous receptors affects this 
      behavior. Intracerebroventricular (i.c.v.) injection of DA or NE inhibited 
      copulation in a dose-dependent manner. Systemic injections of yohimbine, an 
      alpha2-noradrenergic antagonist, modulated copulation in a bimodal manner 
      depending on the dose injected. Interestingly, a behaviorally ineffective dose of 
      yohimbine markedly reduced the inhibitory effects of DA when injected 15min 
      before. Together, these results show for the first time that i.c.v. injections of 
      DA itself inhibit male sexual behavior in quail and suggest that the interaction 
      of DA with alpha2-receptors has behavioral significance.
FAU - Cornil, Charlotte A
AU  - Cornil CA
AD  - Center for Cellular and Molecular Neurobiology, Research Group in Behavioral 
      Neuroendocrinology, University of Liege, B-4020 Liege, Belgium. ccornil@jhu.edu
FAU - Dejace, Christel
AU  - Dejace C
FAU - Ball, Gregory F
AU  - Ball GF
FAU - Balthazart, Jacques
AU  - Balthazart J
LA  - eng
GR  - R01NIH/MH50388/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Receptors, Adrenergic, alpha-2)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - EC 1.14.14.1 (Aromatase)
RN  - N21FAR7B4S (Apomorphine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Aromatase/metabolism
MH  - Coturnix/*physiology
MH  - Dopamine/administration & dosage/*metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraventricular
MH  - Male
MH  - Microinjections
MH  - Norepinephrine/administration & dosage/*metabolism
MH  - Preoptic Area/drug effects/metabolism
MH  - Receptors, Adrenergic, alpha-2/drug effects/*metabolism
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Third Ventricle
MH  - Yohimbine/pharmacology
EDAT- 2005/06/07 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/06/07 09:00
PHST- 2004/12/10 00:00 [received]
PHST- 2005/04/08 00:00 [revised]
PHST- 2005/04/11 00:00 [accepted]
PHST- 2005/06/07 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/06/07 09:00 [entrez]
AID - S0166-4328(05)00186-5 [pii]
AID - 10.1016/j.bbr.2005.04.018 [doi]
PST - ppublish
SO  - Behav Brain Res. 2005 Aug 30;163(1):42-57. doi: 10.1016/j.bbr.2005.04.018.