PMID- 15939085
OWN - NLM
STAT- MEDLINE
DCOM- 20050812
LR  - 20131121
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 157
IP  - 1
DP  - 2005 Jun 9
TI  - Regulation of body temperature by thyrotropin-releasing hormone in neonatal 
      chicks.
PG  - 58-64
AB  - To understand thermal regulation of neonatal chicks, the contribution of 
      thyrotropin-releasing hormone (TRH), a key regulator of the 
      hypothalamus-pituitary-thyroid axis, was investigated. Intracerebroventricular 
      (i.c.v.) injection of TRH (5 and 20 microg) increased body temperature, but did 
      not change plasma T3 and T4 concentrations. Intraperitoneal (i.p.) injection of 
      triiodothyronine (T3) and thyroxine (T4) did not influence body temperature. 
      Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal 
      axis and sympathetic nervous system were further investigated. Central TRH 
      stimulated both corticosterone and epinephrine release. The i.c.v. injection of a 
      corticotropin-releasing factor receptor antagonist attenuated the change in body 
      temperature and corticosterone concentration caused by TRH, but did not influence 
      plasma T3 and T4 concentrations. The i.p. injection of epinephrine did not induce 
      hyperthermia. Therefore, the thermoregulatory response to TRH may differ in 
      neonatal stages being dependent upon the stimulation of the 
      hypothalamus-pituitary-adrenal axis rather than the 
      hypothalamus-pituitary-thyroid axis.
FAU - Takahashi, Hirokazu
AU  - Takahashi H
AD  - Laboratory of Advanced Animal and Marine Bioresources, Graduate School of 
      Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Iigo, Masayuki
AU  - Iigo M
FAU - Ando, Koichi
AU  - Ando K
FAU - Tachibana, Tetsuya
AU  - Tachibana T
FAU - Denbow, D Michael
AU  - Denbow DM
FAU - Furuse, Mitsuhiro
AU  - Furuse M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050412
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Peptide Fragments)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 170809-51-5 (astressin)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - Q51BO43MG4 (Thyroxine)
RN  - W980KJ009P (Corticosterone)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/blood/physiology
MH  - Body Temperature/*drug effects/physiology
MH  - Chickens
MH  - Corticosterone/metabolism
MH  - Corticotropin-Releasing Hormone/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - Drug Interactions
MH  - Epinephrine/metabolism
MH  - Injections, Intraventricular/methods
MH  - Male
MH  - Peptide Fragments/pharmacology
MH  - Thyrotropin-Releasing Hormone/antagonists & inhibitors/*pharmacology
MH  - Thyroxine/administration & dosage/blood
MH  - Triiodothyronine/administration & dosage/blood
EDAT- 2005/06/09 09:00
MHDA- 2005/08/13 09:00
CRDT- 2005/06/09 09:00
PHST- 2004/08/23 00:00 [received]
PHST- 2005/03/06 00:00 [revised]
PHST- 2005/03/10 00:00 [accepted]
PHST- 2005/06/09 09:00 [pubmed]
PHST- 2005/08/13 09:00 [medline]
PHST- 2005/06/09 09:00 [entrez]
AID - S0165-3806(05)00086-6 [pii]
AID - 10.1016/j.devbrainres.2005.03.004 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2005 Jun 9;157(1):58-64. doi: 
      10.1016/j.devbrainres.2005.03.004. Epub 2005 Apr 12.