PMID- 15939267
OWN - NLM
STAT- MEDLINE
DCOM- 20050906
LR  - 20211203
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 41
IP  - 9
DP  - 2005 Jun
TI  - A unique gene having homology with the kinesin family member 18A encodes a 
      tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ 
      colon cancer patients.
PG  - 1323-30
AB  - Colon cancer is one of the major malignant tumours for which the development of a 
      new treatment modality is needed. To provide the scientific basis for a specific 
      immunotherapy for colon cancer, we looked for tumour-associated antigens 
      recognised by cytotoxic T lymphocytes (CTLs) from human leukocyte antigen 
      (HLA)-A2+ colon cancer patients. We report here a unique gene, 3362 base-pairs 
      (bp) long, which has homology with the kinesin family member 18A. This gene was 
      expressed at the mRNA level in the majority of tumour cells, but not in any 
      normal tissues tested except for testis and lung. Two of 16 peptides with 
      HLA-A2-binding motifs were recognised by tumour-reactive CTLs. In addition, these 
      two peptides had the ability to induce HLA-A2-restricted and cancer-reactive CTLs 
      from peripheral blood mononuclear cells (PBMCs) of colon cancer patients with 
      several HLA-A2 subtypes. Overall, this study provides new information about a 
      colon cancer-related antigen that might be an appropriate target for specific 
      immunotherapy in HLA-A2+ colon cancer patients.
FAU - Shichijo, Shigeki
AU  - Shichijo S
AD  - Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka 
      830-0011, Japan.
FAU - Ito, Masaaki
AU  - Ito M
FAU - Azuma, Kouichi
AU  - Azuma K
FAU - Komatsu, Nobukazu
AU  - Komatsu N
FAU - Maeda, Yoshiaki
AU  - Maeda Y
FAU - Ishihara, Yuki
AU  - Ishihara Y
FAU - Nakamura, Toru
AU  - Nakamura T
FAU - Harada, Mamoru
AU  - Harada M
FAU - Itoh, Kyogo
AU  - Itoh K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (DNA, Complementary)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (RNA, Messenger)
RN  - EC 3.6.4.4 (Kinesins)
SB  - IM
MH  - Adenocarcinoma/*genetics/immunology
MH  - Base Sequence/genetics
MH  - Blotting, Northern
MH  - Cell Line, Tumor
MH  - Colonic Neoplasms/*genetics/immunology
MH  - DNA, Complementary/genetics
MH  - HLA-A2 Antigen/*genetics/immunology
MH  - Humans
MH  - Kinesins/*genetics
MH  - RNA, Messenger/metabolism
MH  - Sequence Homology
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2005/06/09 09:00
MHDA- 2005/09/07 09:00
CRDT- 2005/06/09 09:00
PHST- 2004/09/29 00:00 [received]
PHST- 2005/02/15 00:00 [revised]
PHST- 2005/02/17 00:00 [accepted]
PHST- 2005/06/09 09:00 [pubmed]
PHST- 2005/09/07 09:00 [medline]
PHST- 2005/06/09 09:00 [entrez]
AID - S0959-8049(05)00206-6 [pii]
AID - 10.1016/j.ejca.2005.02.025 [doi]
PST - ppublish
SO  - Eur J Cancer. 2005 Jun;41(9):1323-30. doi: 10.1016/j.ejca.2005.02.025.