PMID- 15944376
OWN - NLM
STAT- MEDLINE
DCOM- 20060217
LR  - 20220830
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 25
IP  - 23
DP  - 2005 Jun 8
TI  - Differential response of Period 1 expression within the suprachiasmatic nucleus.
PG  - 5481-7
AB  - The suprachiasmatic nuclei (SCNs) of the hypothalamus contain a circadian clock 
      that exerts profound control over rhythmic physiology and behavior. The clock 
      consists of multiple autonomous cellular pacemakers distributed throughout the 
      rat SCN. In response to a shift in the light schedule, the SCN rapidly changes 
      phase to achieve the appropriate phase relationship with the shifted light 
      schedule. Through use of a transgenic rat in which rhythmicity in transcription 
      of the Period 1 gene was measured with a luciferase reporter (Per1-luc), we have 
      been successful in tracking the time course of molecular rhythm phase 
      readjustments in different regions of the SCN that occur in response to a shift 
      in the light schedule. We find that different regions of the SCN phase adjust at 
      different rates, leading to transient internal desynchrony in Per1-luc expression 
      among SCN regions. This desynchrony among regions is most pronounced and 
      prolonged when the light schedule is advanced compared with light schedule 
      delays. A similar asymmetry in the speed of phase resetting is observed with 
      locomotor behavior, suggesting that phase shifting kinetics within the SCN may 
      underlay the differences observed in behavioral resetting to advances or delays 
      in the light schedule.
FAU - Nakamura, Wataru
AU  - Nakamura W
AD  - Center for Biological Timing and Department of Biology, University of Virginia, 
      Charlottesville, Virginia 22903-2477, USA.
FAU - Yamazaki, Shin
AU  - Yamazaki S
FAU - Takasu, Nana N
AU  - Takasu NN
FAU - Mishima, Kazuo
AU  - Mishima K
FAU - Block, Gene D
AU  - Block GD
LA  - eng
GR  - R01 MH062517/MH/NIMH NIH HHS/United States
GR  - MH62517/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Eye Proteins)
RN  - 0 (Per1 protein, rat)
RN  - 0 (Period Circadian Proteins)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Eye Proteins/*biosynthesis/genetics
MH  - Genes, Reporter
MH  - In Vitro Techniques
MH  - Luciferases/genetics
MH  - Male
MH  - Period Circadian Proteins
MH  - *Periodicity
MH  - *Photoperiod
MH  - Rats
MH  - Suprachiasmatic Nucleus/*metabolism
PMC - PMC6724974
EDAT- 2005/06/10 09:00
MHDA- 2006/02/18 09:00
PMCR- 2005/12/08
CRDT- 2005/06/10 09:00
PHST- 2005/06/10 09:00 [pubmed]
PHST- 2006/02/18 09:00 [medline]
PHST- 2005/06/10 09:00 [entrez]
PHST- 2005/12/08 00:00 [pmc-release]
AID - 25/23/5481 [pii]
AID - 10.1523/JNEUROSCI.0889-05.2005 [doi]
PST - ppublish
SO  - J Neurosci. 2005 Jun 8;25(23):5481-7. doi: 10.1523/JNEUROSCI.0889-05.2005.