PMID- 15944719
OWN - NLM
STAT- MEDLINE
DCOM- 20050909
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 19
IP  - 8
DP  - 2005 Aug
TI  - FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is 
      recurrently targeted by genomic aberrations.
PG  - 1299-305
AB  - The transcription factor Forkhead box protein P1 (FOXP1) is highly expressed in a 
      proportion of diffuse large B-cell lymphoma (DLBCL). In this report, we provide 
      cytogenetic and fluorescence in situ hybridization (FISH) data showing that FOXP1 
      (3p13) is recurrently targeted by chromosome translocations. The genomic 
      rearrangement of FOXP1 was identified by FISH in three cases with a 
      t(3;14)(p13;q32) involving the immunoglobulin heavy chain (IGH) locus, and in one 
      case with a variant t(2;3) affecting sequences at 2q36. These aberrations were 
      associated with strong expression of FOXP1 protein in tumor cells, as 
      demonstrated by immunohistochemistry (IHC). The cases with t(3p13) were diagnosed 
      as DLBCL ( x 1), gastric MALT lymphoma ( x 1) and B-cell non-Hodgkin's lymphoma, 
      not otherwise specified ( x 2). Further IHC and FISH studies performed on 98 
      cases of DLBCL and 93 cases of extranodal marginal zone lymphoma showed a high 
      expression of FOXP1 in approximately 13 and 12% of cases, respectively. None of 
      these cases showed, however, FOXP1 rearrangements by FISH. However, 
      over-representation of the FOXP1 locus found in one additional case of DLBCL may 
      represent another potential mechanism underlying an increased expression of this 
      gene.
CI  - Leukemia (2005) 19, 1299-1305.
FAU - Wlodarska, I
AU  - Wlodarska I
AD  - Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium. 
      Iwona.Wlodarska@uz.kuleuven.ac.be
FAU - Veyt, E
AU  - Veyt E
FAU - De Paepe, P
AU  - De Paepe P
FAU - Vandenberghe, P
AU  - Vandenberghe P
FAU - Nooijen, P
AU  - Nooijen P
FAU - Theate, I
AU  - Theate I
FAU - Michaux, L
AU  - Michaux L
FAU - Sagaert, X
AU  - Sagaert X
FAU - Marynen, P
AU  - Marynen P
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (FOXP1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Aged
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 2
MH  - Chromosomes, Human, Pair 3
MH  - Female
MH  - Forkhead Transcription Factors
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Rearrangement
MH  - Humans
MH  - Lymphoma, B-Cell/genetics
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Male
MH  - Middle Aged
MH  - Repressor Proteins/*genetics
MH  - Retrospective Studies
MH  - *Translocation, Genetic
EDAT- 2005/06/10 09:00
MHDA- 2005/09/10 09:00
CRDT- 2005/06/10 09:00
PHST- 2005/06/10 09:00 [pubmed]
PHST- 2005/09/10 09:00 [medline]
PHST- 2005/06/10 09:00 [entrez]
AID - 2403813 [pii]
AID - 10.1038/sj.leu.2403813 [doi]
PST - ppublish
SO  - Leukemia. 2005 Aug;19(8):1299-305. doi: 10.1038/sj.leu.2403813.