PMID- 15945064
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20190508
IS  - 0887-4476 (Print)
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 57
IP  - 3
DP  - 2005 Sep 1
TI  - Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine 
      (ecstasy) in rats: interaction with exposure in adulthood.
PG  - 148-59
AB  - This study determined whether developmental and adult 
      3,4-methylenedioxymethamphetamine (MDMA) exposures in rats have interactive 
      effects on body temperature, learning, other behaviors, and monoamine 
      concentrations in the hippocampus, prefrontal cortex, and striatum. Learning was 
      assessed in the Cincinnati water maze (CWM), Morris water maze (MWM), and novel 
      object recognition (NOR). On acquisition trials in the MWM, significant 
      differences from developmental MDMA exposure were found on latency, cumulative 
      distance, path length, and angle of first bearing to the goal, but the early and 
      adult MDMA exposure group performed no worse than the developmental-only MDMA 
      group. In the reversal trials, however, an interaction was seen: latency to the 
      goal, cumulative distance, and angle of first bearing were increased in animals 
      treated both developmentally and in adulthood with MDMA compared with those 
      treated only developmentally. Other tests (elevated zero maze, CWM, NOR, and 
      open-field activity) did not show an interaction, nor did hippocampal 
      concentrations of serotonin or dopamine. However, several behavioral tests showed 
      neonatal MDMA effects, including increased errors in the CWM, reduced time spent 
      with a new object in the NOR test, and reduced locomotor activity in the 
      open-field. By contrast, adult MDMA decreased the number of entries into open 
      quadrants of the elevated zero maze. Litter effects were controlled by treating 
      litter as the experimental unit and using mixed models repeated measures 
      analyses. Correlational analyses suggested that the MWM reversal interaction 
      involves multiple monoamine changes. The results indicate that developmental MDMA 
      exposure can interact with adult exposure to interfere with some aspects of 
      learning.
FAU - Cohen, Martha A
AU  - Cohen MA
AD  - Division of Neurology, Cincinnati Children's Research Foundation and University 
      of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
FAU - Skelton, Matthew R
AU  - Skelton MR
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - K01 DA014269-05/DA/NIDA NIH HHS/United States
GR  - R01 DA021394-01/DA/NIDA NIH HHS/United States
GR  - DA14269/DA/NIDA NIH HHS/United States
GR  - DA11902/DA/NIDA NIH HHS/United States
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA021394/DA/NIDA NIH HHS/United States
GR  - T32 ES007051/ES/NIEHS NIH HHS/United States
GR  - ES07051/ES/NIEHS NIH HHS/United States
GR  - R01 DA011902-03/DA/NIDA NIH HHS/United States
GR  - T32 ES007051-34/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/*drug effects
MH  - Biogenic Monoamines/metabolism
MH  - Body Temperature/drug effects
MH  - Brain/anatomy & histology/drug effects/metabolism
MH  - Brain Chemistry/drug effects
MH  - Escape Reaction/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Hallucinogens/*toxicity
MH  - Learning/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Spatial Behavior/drug effects
MH  - Statistics as Topic
MH  - Time Factors
PMC - PMC2888299
MID - NIHMS207855
EDAT- 2005/06/10 09:00
MHDA- 2005/10/28 09:00
PMCR- 2010/06/21
CRDT- 2005/06/10 09:00
PHST- 2005/06/10 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/06/10 09:00 [entrez]
PHST- 2010/06/21 00:00 [pmc-release]
AID - 10.1002/syn.20166 [doi]
PST - ppublish
SO  - Synapse. 2005 Sep 1;57(3):148-59. doi: 10.1002/syn.20166.