PMID- 15946313
OWN - NLM
STAT- MEDLINE
DCOM- 20050815
LR  - 20171116
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 75
IP  - 1
DP  - 2005 Jul
TI  - Pericardial graft vs. host disease in a patient with myelodysplastic syndrome 
      following peripheral blood stem cell transplantation.
PG  - 65-7
AB  - A patient with myelodysplastic syndrome developed pericardial effusion 20 month 
      after allogenic peripheral blood stem cell transplantation. Sclerotic and 
      erythematous skin lesions were observed over the face and extremities, and a 
      diagnosis of chronic graft vs. host disease (GVHD) was made based on skin biopsy 
      findings. Pericardial fluid contained numerous CD8+/HLA-DR+ lymphocytes, but no 
      leukaemic cells. Tumour necrosis factor alpha (TNFalpha) and soluble Fas (sFas) 
      levels were highly elevated in both the effusion and serum. The patient was 
      treated with methylprednisolone and tacrolimus. Skin GVHD improved rapidly 
      associated with resolution of pericardial effusion and reductions in cytokine 
      levels. We concluded that pericardial effusion was due to pericarditis and was a 
      manifestation of chronic GVHD in this patient, and that cytotoxic lymphocytes and 
      specific cytokines played significant roles.
CI  - (c) Blackwell Munksgaard 2005.
FAU - Saito, Yasuyuki
AU  - Saito Y
AD  - Department of Medicine and Clinical Science, Gunma University Graduate School of 
      Medicine, 3-39-33 Showa-machi, Maebashi, Gunma 371-8511, Japan. 
      yass-gnm@umin.ac.jp
FAU - Matsushima, Takafumi
AU  - Matsushima T
FAU - Doki, Noriko
AU  - Doki N
FAU - Tsumita, Yuki
AU  - Tsumita Y
FAU - Takizawa, Makiko
AU  - Takizawa M
FAU - Yokohama, Akihiko
AU  - Yokohama A
FAU - Handa, Hiroshi
AU  - Handa H
FAU - Tsukamoto, Norifumi
AU  - Tsukamoto N
FAU - Karasawa, Masamitsu
AU  - Karasawa M
FAU - Murakami, Hirokazu
AU  - Murakami H
FAU - Nojima, Yoshihisa
AU  - Nojima Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Chronic Disease
MH  - Female
MH  - Graft vs Host Disease/blood/complications/*drug therapy
MH  - HLA-DR Antigens/blood
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage
MH  - Myelodysplastic Syndromes/blood/complications/*therapy
MH  - Pericarditis/blood/*drug therapy/etiology
MH  - Pericardium/physiopathology
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Tacrolimus/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - fas Receptor/blood
EDAT- 2005/06/11 09:00
MHDA- 2005/08/16 09:00
CRDT- 2005/06/11 09:00
PHST- 2005/06/11 09:00 [pubmed]
PHST- 2005/08/16 09:00 [medline]
PHST- 2005/06/11 09:00 [entrez]
AID - EJH425 [pii]
AID - 10.1111/j.1600-0609.2005.00425.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2005 Jul;75(1):65-7. doi: 10.1111/j.1600-0609.2005.00425.x.