PMID- 15946462
OWN - NLM
STAT- MEDLINE
DCOM- 20050802
LR  - 20071205
IS  - 0960-8923 (Print)
IS  - 0960-8923 (Linking)
VI  - 15
IP  - 5
DP  - 2005 May
TI  - Changes in insulin resistance following bariatric surgery and the adipoinsular 
      axis: role of the adipocytokines, leptin, adiponectin and resistin.
PG  - 692-9
AB  - The fat mass participates in the regulation of glucose and insulin metabolism 
      through the release of adipocytokines in a mechanism called the adipoinsular 
      axis. Putative adipocytokines include leptin, adiponectin and resistin. Obesity 
      plays an important role in the pathogenesis of insulin resistance and type 2 
      diabetes mellitus (T2DM). Bariatric surgery for morbidly obese patients leads to 
      rapid and prolonged improvement in insulin resistance and T2DM in the vast 
      majority of patients. We have previously proposed that the rapid improvement in 
      insulin resistance observed following bariatric surgery is mediated by changes in 
      incretin levels of the entero-insular axis and that long-term improvement is 
      modulated by fat mass loss and changes in adipocytokine levels of the 
      adipoinsular axis. In this review, we examine the information that supports a 
      role of leptin, adiponectin and resistin in the development of insulin resistance 
      and T2DM. Increasing levels of leptin and decreasing levels of adiponectin 
      correlate with worsening insulin resistance in obese individuals. We also explore 
      the relationship between changes in adipocytokines following bariatric surgery 
      and long-term improvement in insulin resistance and T2DM. Leptin levels drop and 
      adiponectin levels rise following laparoscopic adjustable gastric banding, 
      gastric bypass and biliopancreatic diversion. These changes correlate with weight 
      loss and improvement in insulin. Although resistin may play an important role in 
      explaining insulin resistance, animal and human studies currently show 
      conflicting results.
FAU - Ballantyne, Garth H
AU  - Ballantyne GH
AD  - Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. 
      ghb@lapsurgery.com
FAU - Gumbs, Andrew
AU  - Gumbs A
FAU - Modlin, Irvin M
AU  - Modlin IM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Adiponectin)
RN  - 0 (Hormones, Ectopic)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Leptin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Adiponectin
MH  - Animals
MH  - *Gastric Bypass
MH  - Hormones, Ectopic/*blood
MH  - Humans
MH  - *Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Leptin/blood
MH  - Obesity, Morbid/*blood/surgery
MH  - Resistin
RF  - 101
EDAT- 2005/06/11 09:00
MHDA- 2005/08/03 09:00
CRDT- 2005/06/11 09:00
PHST- 2005/06/11 09:00 [pubmed]
PHST- 2005/08/03 09:00 [medline]
PHST- 2005/06/11 09:00 [entrez]
AID - 10.1381/0960892053923789 [doi]
PST - ppublish
SO  - Obes Surg. 2005 May;15(5):692-9. doi: 10.1381/0960892053923789.