PMID- 15946507
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20090710
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 26
IP  - 1
DP  - 2005 Jan
TI  - [Clinical and experimental study of two cases of myelodysplastic syndromes with 
      double isochromosome 20q- anomaly].
PG  - 35-8
AB  - OBJECTIVE: To explore the clinical and laboratory characteristics of two 
      myelodysplastic syndromes (MDS) patients with double isochromosome 20q- anomaly. 
      METHODS: Bone marrow cell chromosome preparations were made with both direct 
      method and short-term culture. Karyotype analysis was performed by R-banding 
      technique, and dual-color FISH (fluorescence in situ hybridization) by using a 
      20q telomeric probe and a sequence-specific probe for 20q12. RESULTS: The 
      clinical and hematological findings were comparable with diagnosis of MDS. 
      Karyotype analysis showed that both patients had double isochromosome 20q- 
      anomaly: case 1 is 46, XX, der(20)? i(20q-) [6]/46, idem, der (6) i (6p) [1]/47, 
      idem, +der (20)? i (20q-) [3]/47, idem, der(6)i (6p), +der(20)? i (20q-) [20]; 
      case 2 is 45, XY, -7, der (20)? i (20q-) [17]/46, idem, +der(20) ? i(20q-) [3]. 
      Two derivative chromosomes 20 were proved 20q isochromosomes with interstitial 
      deletions by dual-color FISH in one patient. CONCLUSIONS: Double isochromosome 
      20q- anomaly is a rare recurrent karyotype abnormality in MDS, and signals a poor 
      prognosis.
FAU - Gong, Sheng-lan
AU  - Gong SL
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, China.
FAU - Xue, Yong-quan
AU  - Xue YQ
FAU - Wang, Jian-min
AU  - Wang JM
FAU - Han, Feng-lai
AU  - Han FL
FAU - Xu, Yan-qun
AU  - Xu YQ
FAU - Li, Jin-ying
AU  - Li JY
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 2005/06/11 09:00
MHDA- 2009/01/27 09:00
CRDT- 2005/06/11 09:00
PHST- 2005/06/11 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2005/06/11 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2005 Jan;26(1):35-8.