PMID- 15948796
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20080317
IS  - 1395-3907 (Print)
IS  - 1395-3907 (Linking)
VI  - 83
IP  - 3
DP  - 2005 Jun
TI  - Chromosomal imbalances in some benign orbital tumours.
PG  - 385-91
AB  - PURPOSE: To examine benign orbital tumours for chromosomal imbalances. METHODS: 
      Specimens obtained from orbital tumours were screened for chromosomal imbalances 
      using high resolution comparative genomic hybridization (CGH). The imbalances 
      detected by CGH were confirmed by using fluorescence in situ hybridization (FISH) 
      and loss of heterozygosity (LOH) analysis. RESULTS: Chromosomal gains or losses 
      were seen in 4/6 pleomorphic adenomas (gains at 8q; losses at 4p, 5p, 8p, 11p and 
      14q), 2/4 schwannomas (losses at 16p and 22q), and 1/9 cavernous haemangiomas 
      (losses at 13q). Compared to previous studies of pleomorphic adenomas using 
      G-band analysis, chromosomal imbalances were more frequently detected by using 
      CGH. Gains of 8q11-q22 and losses of 4p15-pter, 11p12-p15, and 14q12-q23 in 
      pleomorphic adenomas, losses of 16p12-p13 in schwannomas, and losses of 
      13q32-qter in cavernous haemangiomas have not been reported previously. 
      CONCLUSIONS: A range of chromosomal imbalances was detected even within tumours 
      of the same histological subtype. We did not observe common chromosomal gains or 
      losses that were characteristic for orbital presentation of the tumours. The 
      clinical relevance of the abnormalities is uncertain, but they may indicate the 
      position of genes that could play a role in tumour development.
FAU - Rodahl, Eyvind
AU  - Rodahl E
AD  - Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway. 
      eyvind.rodahl@helse-bergen.no
FAU - Lybaek, Helle
AU  - Lybaek H
FAU - Arnes, Jarle
AU  - Arnes J
FAU - Ness, Gro Oddveig
AU  - Ness GO
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Acta Ophthalmol Scand
JT  - Acta ophthalmologica Scandinavica
JID - 9507578
SB  - IM
MH  - Adenoma, Pleomorphic/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Female
MH  - Hemangioma, Cavernous/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Neurilemmoma/*genetics/pathology
MH  - Nucleic Acid Hybridization
MH  - Orbital Neoplasms/*genetics/pathology
MH  - Polymerase Chain Reaction
EDAT- 2005/06/14 09:00
MHDA- 2005/07/12 09:00
CRDT- 2005/06/14 09:00
PHST- 2005/06/14 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2005/06/14 09:00 [entrez]
AID - AOS460 [pii]
AID - 10.1111/j.1600-0420.2005.00460.x [doi]
PST - ppublish
SO  - Acta Ophthalmol Scand. 2005 Jun;83(3):385-91. doi: 
      10.1111/j.1600-0420.2005.00460.x.