PMID- 15949496
OWN - NLM
STAT- MEDLINE
DCOM- 20050822
LR  - 20051116
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 233
IP  - 1-2
DP  - 2005 Jun 15
TI  - Intravenous immunoglobulin treatment of multiple sclerosis and its animal model, 
      experimental autoimmune encephalomyelitis.
PG  - 61-5
AB  - Intravenous immunoglobulin (IVIG) is an established treatment of immune-mediated 
      demyelinating neuropathy. Since IVIG possesses multiple immunomodulatory and 
      anti-inflammatory properties, IVIG therapy may represent a way of interfering 
      with the disease process in multiple sclerosis (MS). In the MS animal model 
      experimental autoimmune encephalomyelitis (EAE), infusions of IVIG significantly 
      reduced disease symptoms as well as the underlying CNS pathology. IVIG was only 
      effective in EAE when administered in a prophylactic treatment protocol, since 
      IVIG infusions during the established phase of EAE did not alter the disease 
      course or the degree of inflammation found in the central nervous system. IVIG 
      also has the potential to act through myelin repair mechanisms as evidenced by 
      work done in the Theilers murine encephalomyelitis virus model of demyelination. 
      Together these observations have led to certain expectations for IVIG as a 
      treatment for MS, and have resulted in various clinical trials. Several 
      controlled trials report beneficial effects of IVIG on relapse rate, new MRI 
      lesions, and disease progression in relapsing-remitting MS, while a remyelinating 
      effect of IVIG has not been documented. IVIG is, therefore, presently regarded as 
      a second-line therapy of MS.
FAU - Humle Jorgensen, Signe
AU  - Humle Jorgensen S
AD  - Copenhagen MS Centre, Department of Neurology, Copenhagen University Hospital, 
      Rigshospitalet, DK-2100 Copenhagen, Denmark. shumle@nru.dk
FAU - Sorensen, Per Soelberg
AU  - Sorensen PS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20050422
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Multiple Sclerosis/*therapy
RF  - 26
EDAT- 2005/06/14 09:00
MHDA- 2005/08/23 09:00
CRDT- 2005/06/14 09:00
PHST- 2005/06/14 09:00 [pubmed]
PHST- 2005/08/23 09:00 [medline]
PHST- 2005/06/14 09:00 [entrez]
AID - S0022-510X(05)00083-3 [pii]
AID - 10.1016/j.jns.2005.03.005 [doi]
PST - ppublish
SO  - J Neurol Sci. 2005 Jun 15;233(1-2):61-5. doi: 10.1016/j.jns.2005.03.005. Epub 
      2005 Apr 22.