PMID- 15951008
OWN - NLM
STAT- MEDLINE
DCOM- 20050926
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 81
IP  - 3
DP  - 2005 Jul
TI  - MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females.
PG  - 635-44
AB  - In Experiment 1, we assessed the effects of 3,4-methylenedioxymethamphetamine 
      (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. 
      Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient 
      temperature 25 degrees C) three times at 2 h intervals. Initially, females showed 
      greater locomotor activation by the drug than males, however after the second 
      injection, males showed greater hyperlocomotion. After the third injection, 3 of 
      10 females and all of the males died. In the surviving females, we observed 
      serotonin depletion in cortex and hippocampus, but catecholaminergic markers were 
      unaltered. In Experiment 2, male and female rats were repeatedly injected with 
      saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient 
      temperature 21.5 degrees C). After the third injection of 10 mg/kg MDMA, the 
      MDMA-induced hyperthermia was greater in males than in females (about +0.8 
      degrees C); at the lower dose, no difference was observed. Probably because of 
      the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA 
      treatment, and MDMA induced less serotonin depletion than in the first 
      experiment, with no difference between females and males. Thus, pubescent males 
      appear to be more sensitive than females to locomotor and hyperpyretic effects of 
      MDMA. This sex-dependent effect, which is at variance with previously reported 
      dimorphisms in psychostimulant effects, is discussed in terms of possible 
      differences in dopamine D1 and D2 receptors at pubescence, or other factors 
      related to drug metabolism.
FAU - Koenig, Julie
AU  - Koenig J
AD  - Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 
      CNRS-Universite Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue 
      Goethe, F-67000 Strasbourg, France.
FAU - Lazarus, Christine
AU  - Lazarus C
FAU - Jeltsch, Helene
AU  - Jeltsch H
FAU - Ben Hamida, Sami
AU  - Ben Hamida S
FAU - Riegert, Celine
AU  - Riegert C
FAU - Kelche, Christian
AU  - Kelche C
FAU - Jones, Byron C
AU  - Jones BC
FAU - Cassel, Jean-Christophe
AU  - Cassel JC
LA  - eng
GR  - AG 21190/AG/NIA NIH HHS/United States
GR  - NS 35088/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/drug effects/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology/toxicity
MH  - Norepinephrine/metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Serotonin/metabolism
MH  - Sex Factors
MH  - Sexual Maturation/*physiology
MH  - Survival Rate
MH  - Time Factors
EDAT- 2005/06/14 09:00
MHDA- 2005/09/27 09:00
CRDT- 2005/06/14 09:00
PHST- 2004/06/07 00:00 [received]
PHST- 2005/04/19 00:00 [revised]
PHST- 2005/04/22 00:00 [accepted]
PHST- 2005/06/14 09:00 [pubmed]
PHST- 2005/09/27 09:00 [medline]
PHST- 2005/06/14 09:00 [entrez]
AID - S0091-3057(05)00165-6 [pii]
AID - 10.1016/j.pbb.2005.04.014 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2005 Jul;81(3):635-44. doi: 10.1016/j.pbb.2005.04.014.