PMID- 15951395
OWN - NLM
STAT- MEDLINE
DCOM- 20060410
LR  - 20181113
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 92
IP  - 3
DP  - 2006 Mar
TI  - Mitral valve repair for active culture positive infective endocarditis.
PG  - 361-3
AB  - OBJECTIVE: To describe the clinical and echocardiographic outcome after mitral 
      valve (MV) repair for active culture positive infective MV endocarditis. PATIENTS 
      AND METHODS: Between 1996 and 2004, 36 patients (mean (SD) age 53 (18) years) 
      with positive blood culture up to three weeks before surgery (or positive culture 
      of material removed at operation) and intraoperative evidence of endocarditis 
      underwent MV repair. Staphylococci and streptococci were the most common 
      pathogens. All patients had moderate or severe mitral regurgitation (MR). Mean 
      New York Heart Association (NYHA) class was 2.3 (1.0). Follow up was complete 
      (mean 38 (19) months). RESULTS: Operative mortality was 2.8% (one patient). At 
      follow up, endocarditis has not recurred. One patient developed severe recurrent 
      MR and underwent valve replacement and one patient had moderate MR. There were 
      two late deaths, both non-cardiac. Kaplan-Meier five year freedom from recurrent 
      moderate to severe MR, freedom from repeat operation, and survival were 94 (4)%, 
      97 (3)%, and 93 (5)%, respectively. At the most recent review the mean NYHA class 
      was 1.17 (0.3) (p < 0.0001). At the latest echocardiographic evaluation, left 
      atrial diameters, left ventricular end diastolic diameter, and MV diameter were 
      significantly reduced (p < 0.05) compared with preoperative values. CONCLUSIONS: 
      MV repair for active culture positive endocarditis is associated with low 
      operative mortality and provides satisfactory freedom from recurrent infection, 
      freedom from repeat operation, and survival. Hence, every effort should be made 
      to repair infected MVs and valves should be replaced only when repair is not 
      possible.
FAU - Doukas, G
AU  - Doukas G
AD  - Department of Cardiac Surgery, Glenfield Hospital, University of Leicester, 
      Leicester, UK.
FAU - Oc, M
AU  - Oc M
FAU - Alexiou, C
AU  - Alexiou C
FAU - Sosnowski, A W
AU  - Sosnowski AW
FAU - Samani, N J
AU  - Samani NJ
FAU - Spyt, T J
AU  - Spyt TJ
LA  - eng
PT  - Journal Article
DEP - 20050610
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
CIN - Heart. 2006 Mar;92(3):289-90. PMID: 16216851
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Echocardiography
MH  - Endocarditis, Bacterial/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*surgery
MH  - Mitral Valve Insufficiency/microbiology/*surgery
MH  - Postoperative Care/methods
MH  - Treatment Outcome
PMC - PMC1860805
EDAT- 2005/06/14 09:00
MHDA- 2006/04/11 09:00
PMCR- 2009/03/01
CRDT- 2005/06/14 09:00
PHST- 2005/06/14 09:00 [pubmed]
PHST- 2006/04/11 09:00 [medline]
PHST- 2005/06/14 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - hrt.2004.059063 [pii]
AID - ht59063 [pii]
AID - 10.1136/hrt.2004.059063 [doi]
PST - ppublish
SO  - Heart. 2006 Mar;92(3):361-3. doi: 10.1136/hrt.2004.059063. Epub 2005 Jun 10.