PMID- 15952108
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20050613
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 22
IP  - 3
DP  - 2005 Jun
TI  - Detection of chromosome aberrations in Chinese children with autism using 
      G-banding and BAC FISH.
PG  - 254-7
AB  - OBJECTIVE: To detect the characteristic chromosomal changes in Chinese children 
      with infantile autism. METHODS: Chromosome aberrations in 68 cases of infantile 
      autism were analyzed by high-resolution G-banding and fluorescence in situ 
      hybridization (FISH) with bacterial artificial chromosome (BAC) clones. RESULTS: 
      Chromosomal changes were detected in 4 cases by high-resolution G-banding: one 
      case with t(4;6)(q23-24;p21), one case with longer p arm of chromosome 21 (21p+), 
      and two cases with pericentric inversion of chromosome 9 (inv(9)) which was 
      confirmed by C-banding. BAC FISH analysis was performed to confirm these 
      observations and changes in chromosomes 2, 7 and 15, which are often found in 
      autistic children. There could exist the translocation of t(4;6) (q25-26;p21.1). 
      Chromosome changes often reported previously in chromosomes 2, 7 and 15 were not 
      detected in this study. Inv(9) and 21p+ were not confirmed with present BAC 
      clones. CONCLUSION: Chromosomal changes were detected in four cases of infantile 
      autism, with a detectability of 5.9% , far lower than that (10% to 48%) reported 
      in literature. The breakpoint of translocation could be detected more accurately 
      using BAC FISH method.
FAU - Liu, Qing-jie
AU  - Liu QJ
AD  - Chinese National Human Genome Center, Beijing, 100176, PR China.
FAU - Ma, Fen
AU  - Ma F
FAU - Li, Dan
AU  - Li D
FAU - Wang, Xiao-wei
AU  - Wang XW
FAU - Tian, Wen-yan
AU  - Tian WY
FAU - Chen, Yan
AU  - Chen Y
FAU - Feng, Jiang-bin
AU  - Feng JB
FAU - Lu, Xue
AU  - Lu X
FAU - Chen, De-qing
AU  - Chen DQ
FAU - Chen, Xiao-Ning
AU  - Chen XN
FAU - Shen, Yan
AU  - Shen Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Autistic Disorder/diagnosis/*genetics
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosomes, Artificial, Bacterial/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2005/06/14 09:00
MHDA- 2009/03/20 09:00
CRDT- 2005/06/14 09:00
PHST- 2005/06/14 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2005/06/14 09:00 [entrez]
AID - 940622061 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Jun;22(3):254-7.