PMID- 15952985
OWN - NLM
STAT- MEDLINE
DCOM- 20050921
LR  - 20221207
IS  - 0009-9163 (Print)
IS  - 0009-9163 (Linking)
VI  - 68
IP  - 1
DP  - 2005 Jul
TI  - Chromosomal changes in prostate cancer: a fluorescence in situ hybridization 
      study.
PG  - 40-7
AB  - The incidence of prostate cancer (PC) is increasing steadily with the aging 
      population in Singapore. As the pattern of chromosomal aberrations in Asian men 
      with PC is poorly understood, we investigated the numerical aberrations for 
      chromosomes 7, 8, 11, and 17 by fluorescence in situ hybridization (FISH). FISH 
      was performed on standard sections and tissue microarrays of 54 PC and 33 benign 
      prostatic hyperplasia (BPH) specimens. Among the 54 PC specimens, FISH detected 
      44 cases as aneusomy and two as disomy and was unsuccessful for eight cases. 
      Cytogenetic alterations of two or more chromosomes per tumor were detected in 
      33/46 (72%) PCs. The most frequent alteration was aneusomy of chromosome 8 
      detected in 34/46 (74%) cases followed by numerical aberrations in chromosome 7 
      (61%). Gain of 8q24, loss of chromosome 7, and gain of 11q13 were associated with 
      higher Gleason score and were statistically significant. Gain of chromosome 7 was 
      more common in locally advanced disease, while gain of chromosome 11q13 and 
      chromosome 7 was more common in metastatic disease.
FAU - Das, K
AU  - Das K
AD  - Department of Urology, Singapore General Hospital, Singapore. gurkd@sgh.com.sg
FAU - Lau, W
AU  - Lau W
FAU - Sivaswaren, Cr
AU  - Sivaswaren C
FAU - Ph, Tan
AU  - Ph T
FAU - Fook-Chong, Smc
AU  - Fook-Chong S
FAU - Sl, Tien
AU  - Sl T
FAU - Cheng, C
AU  - Cheng C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asia
MH  - Asian People/genetics
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Prostatic Hyperplasia/genetics
MH  - Prostatic Neoplasms/*genetics
MH  - Singapore/ethnology
MH  - Sweden
MH  - White People/genetics
EDAT- 2005/06/15 09:00
MHDA- 2005/09/22 09:00
CRDT- 2005/06/15 09:00
PHST- 2005/06/15 09:00 [pubmed]
PHST- 2005/09/22 09:00 [medline]
PHST- 2005/06/15 09:00 [entrez]
AID - CGE452 [pii]
AID - 10.1111/j.1399-0004.2005.00452.x [doi]
PST - ppublish
SO  - Clin Genet. 2005 Jul;68(1):40-7. doi: 10.1111/j.1399-0004.2005.00452.x.