PMID- 15953578
OWN - NLM
STAT- MEDLINE
DCOM- 20050823
LR  - 20111117
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 140
IP  - 1
DP  - 2005 Jul
TI  - Phlyctenular keratitis associated with meibomitis in young patients.
PG  - 77-82
AB  - PURPOSE: To describe the unique clinical features of phlyctenular keratitis, 
      including the association with meibomitis, in young patients. DESIGN: 
      Observational case series. METHODS: The study population consisted of 23 Japanese 
      patients aged under 35 years with phlyctenular keratitis. We examined their 
      clinical history, signs and symptoms, human leukocyte antigen (HLA), bacterial 
      cultures of meibum, and the efficacy of antibiotics. The minimal diagnostic 
      criteria included corneal nodules consisting of cellular infiltrates and 
      superficial neovascularization. RESULTS: Of the 23 patients, 20 (87%) were women, 
      and 13 (56.5%) had a history of chalazia. In all cases, the lesions and the 
      severity of corneal nodules and neovascularization corresponded well with the 
      location and the severity of meibomitis. The frequency of HLA-A26 and HLA-B35 was 
      significantly increased in our patients (P = .003 and .016, respectively). 
      Propionibacterium acnes in bacterial cultures of pure meibum in 12 of the 20 
      patients (60%) was statistically more highly positive than those in four of the 
      17 age-matched normal control subjects (23.5%; P = .028). CONCLUSION: The 
      characteristics of phlyctenular keratitis in our cases include significantly 
      higher prevalence in female patients, severity variation of ocular surface 
      manifestation corresponding to meibomitis, specific HLA association, and possible 
      P. acnes involvement.
FAU - Suzuki, Tomo
AU  - Suzuki T
AD  - Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan. 
      tsuzuki@ophth.kpu-m.ac.jp
FAU - Mitsuishi, Yoko
AU  - Mitsuishi Y
FAU - Sano, Yoichiro
AU  - Sano Y
FAU - Yokoi, Norihiko
AU  - Yokoi N
FAU - Kinoshita, Shigeru
AU  - Kinoshita S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-B35 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blepharitis/*complications/microbiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA-A Antigens/metabolism
MH  - HLA-B35 Antigen/metabolism
MH  - Humans
MH  - Infant
MH  - Keratitis/*complications/metabolism
MH  - Male
MH  - Meibomian Glands/*pathology
MH  - Propionibacterium acnes/isolation & purification
MH  - Sebum/microbiology
MH  - Sex Factors
EDAT- 2005/06/15 09:00
MHDA- 2005/08/24 09:00
CRDT- 2005/06/15 09:00
PHST- 2004/11/22 00:00 [received]
PHST- 2005/02/16 00:00 [revised]
PHST- 2005/02/11 00:00 [accepted]
PHST- 2005/06/15 09:00 [pubmed]
PHST- 2005/08/24 09:00 [medline]
PHST- 2005/06/15 09:00 [entrez]
AID - S0002-9394(05)00262-X [pii]
AID - 10.1016/j.ajo.2005.02.039 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2005 Jul;140(1):77-82. doi: 10.1016/j.ajo.2005.02.039.