PMID- 15954084
OWN - NLM
STAT- MEDLINE
DCOM- 20051107
LR  - 20151119
IS  - 1542-9733 (Print)
IS  - 1542-9733 (Linking)
VI  - 74
IP  - 3
DP  - 2005 Jun
TI  - Postnatal development of rat pups after maternal exposure to diethanolamine.
PG  - 243-54
AB  - BACKGROUND: Diethanolamine (DEA), a widely used surfactant, was administered to 
      pregnant mice at the oral LD10 resulting in failure of pups to grow and thrive 
      through postnatal day (PND) 3 [National Toxicology Program, 1987; York et al., 
      Teratology 37:503-504, 1988]. The toxicity profile for DEA differs among rodent 
      species. This study investigated DEA-induced postnatal toxicity in a second 
      species. METHODS: Timed-mated Sprague-Dawley rats were dosed (0, 50, 125, 200, 
      250, or 300 mg DEA/kg/day, p.o.) on gestational days (GD) 6-19. Dams and pups 
      were monitored for body weight, feed/water intake, clinical signs, litter size, 
      and sex ratio. At necropsy (PND 21), maternal liver and kidney weights and number 
      of uterine implantation sites were recorded. RESULTS: The high-dose group was 
      terminated early due to excessive toxicity. The estimated maternal LD10 was 218 
      mg/kg/day. Maternal effects included decreased body weight and relative feed 
      intake (>or=200 mg/kg/day), transiently reduced relative water intake (125 and 
      250 mg/kg/day), and increased absolute kidney weight (>or=125 mg/kg/day). 
      Postimplantation loss (PND 0) and pup mortality (PND 0-4) were increased (>or=200 
      and >or=125 mg/kg/day, respectively). Pup body weight was reduced (>or=200 
      mg/kg/day) as late as PND 21. CONCLUSIONS: This study demonstrates reduced 
      postnatal growth and survival in a second species after gestational exposure to 
      DEA, persistence of toxic effects through the end of lactation, possibly due to 
      long elimination half-life, and maternal and developmental toxicity 
      no-observed-adverse-effect level (NOAELs) (50 mg/kg/day) and 
      lowest-observed-adverse-effect level (LOAELs) (125 mg/kg/day) for oral DEA 
      exposure during embryo/fetal development in the rat.
CI  - Copyright (c) 2005 Wiley-Liss, Inc.
FAU - Price, Catherine J
AU  - Price CJ
AD  - Life Sciences and Toxicology, RTI International, Research Triangle Park, North 
      Carolina 27709-2194, USA. cjp@rti.org
FAU - Marr, Melissa C
AU  - Marr MC
FAU - Myers, Christina B
AU  - Myers CB
FAU - Jahnke, Gloria D
AU  - Jahnke GD
LA  - eng
GR  - N01-ES-65405/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Birth Defects Res B Dev Reprod Toxicol
JT  - Birth defects research. Part B, Developmental and reproductive toxicology
JID - 101155115
RN  - 0 (Ethanolamines)
RN  - AZE05TDV2V (diethanolamine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Eating/drug effects
MH  - Ethanolamines/*toxicity
MH  - Female
MH  - Growth and Development/drug effects
MH  - *Maternal Exposure
MH  - No-Observed-Adverse-Effect Level
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/06/15 09:00
MHDA- 2005/11/08 09:00
CRDT- 2005/06/15 09:00
PHST- 2005/06/15 09:00 [pubmed]
PHST- 2005/11/08 09:00 [medline]
PHST- 2005/06/15 09:00 [entrez]
AID - 10.1002/bdrb.20044 [doi]
PST - ppublish
SO  - Birth Defects Res B Dev Reprod Toxicol. 2005 Jun;74(3):243-54. doi: 
      10.1002/bdrb.20044.