PMID- 15954904
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20220224
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 68
IP  - 1
DP  - 2005 Jul
TI  - Renal expression of SIBLING proteins and their partner matrix metalloproteinases 
      (MMPs).
PG  - 155-66
AB  - BACKGROUND: Three members of the small integrin-binding ligand N-linked 
      glycoprotein (SIBLING) family of proteins have recently been shown to bind and 
      activate specific promatrix metalloproteinases (MMPs) and to overcome the 
      inhibition of tissue inhibitors of MMPs (TIMPs). Although usually associated with 
      mineralized tissues, we have shown that the SIBLINGs and their MMP partners, when 
      known, are coexpressed in salivary gland ductal cells. The present study examined 
      the expression patterns of both the SIBLINGs and their MMP partners in adult 
      kidney. METHODS: The expression patterns of all five SIBLINGs known to date, and 
      their MMP partners were determined in monkey kidney using immunohistochemistry 
      and in situ hybridization techniques. RESULTS: Bone sialoprotein (BSP) and its 
      partner, MMP-2, were coexpressed in both the proximal and distal tubules. 
      Osteopontin, as previously shown, was expressed in the distal tubules while its 
      partner MMP-3 was expressed in both the proximal tubule and distal tubles. Dentin 
      matrix protein-1 (DMP1) and MMP-9 were coexpressed throughout the nephron, 
      including both parietal cells of Bowman's capsule and the thin limb of the loop 
      of Henle. Dentin sialophosphoprotein (DSPP) and matrix extracellular 
      phosphoglycoprotein (MEPE) were expressed in the proximal tubule and distal 
      tubule, and proximal tubule, respectively. CONCLUSION: In contrast to salivary 
      gland in which all SIBLINGs and their MMP partners were coexpressed throughout 
      the length of the ducts, these proteins were differentially expressed within the 
      normal adult nephron. We hypothesize that the cells use the SIBLING/MMP pairs in 
      the normal turnover of cell surface proteins and/or pericellular matrix proteins 
      such as those in basement membranes.
FAU - Ogbureke, Kalu U E
AU  - Ogbureke KU
AD  - Matrix Biochemistry Section, Craniofacial and Skeletal Disease Branch, National 
      Institute of Dental and Craniofacial Research, National Institutes of Health, 
      DHHS, Bethesda, Maryland 20982-4320, USA.
FAU - Fisher, Larry W
AU  - Fisher LW
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (DMP1 protein, human)
RN  - 0 (Dmp1 protein, mouse)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (IBSP protein, human)
RN  - 0 (Ibsp protein, mouse)
RN  - 0 (Ibsp protein, rat)
RN  - 0 (Integrin-Binding Sialoprotein)
RN  - 0 (Integrins)
RN  - 0 (MEPE protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (Protein Precursors)
RN  - 0 (SPP1 protein, human)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Spp1 protein, mouse)
RN  - 0 (Spp1 protein, rat)
RN  - 0 (dentin sialophosphoprotein)
RN  - 106441-73-0 (Osteopontin)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix Proteins/genetics/metabolism
MH  - Glycoproteins/*genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Integrin-Binding Sialoprotein
MH  - Integrins/metabolism
MH  - Kidney/*physiology
MH  - Macaca fascicularis
MH  - Matrix Metalloproteinase 2/genetics/metabolism
MH  - Matrix Metalloproteinase 3/genetics/metabolism
MH  - Matrix Metalloproteinase 9/genetics/metabolism
MH  - Matrix Metalloproteinases/*genetics/*metabolism
MH  - Mice
MH  - Osteopontin
MH  - Phosphoproteins/genetics/metabolism
MH  - Protein Precursors/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sialoglycoproteins/genetics/metabolism
EDAT- 2005/06/16 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/16 09:00
PHST- 2005/06/16 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/16 09:00 [entrez]
AID - S0085-2538(15)50822-3 [pii]
AID - 10.1111/j.1523-1755.2005.00389.x [doi]
PST - ppublish
SO  - Kidney Int. 2005 Jul;68(1):155-66. doi: 10.1111/j.1523-1755.2005.00389.x.