PMID- 15957953
OWN - NLM
STAT- MEDLINE
DCOM- 20050908
LR  - 20061115
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 25
IP  - 6
DP  - 2005 Jun
TI  - Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in 
      immune reactions.
PG  - 297-310
AB  - Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional complex that has 
      been recognized primarily for its role in the maintenance of oxygen and energy 
      homoeostasis. The HIF-1alpha subunit is O(2) labile and is degraded by the 
      proteasome following prolyl-hydroxylation and ubiquitination in normoxic cells. 
      The present review summarizes evidence that HIF-1 is also involved in immune 
      reactions. Immunomodulatory peptides, including interleukin-1 (IL-1) and tumor 
      necrosis factor-alpha (TNF-alpha), stimulate HIF-1 dependent gene expression even 
      in normoxic cells. Both the hypoxic and the cytokine-induced activation of HIF-1 
      involve the phosphatidylinositol- 3-kinase (PI3K) and the mitogen-activated 
      protein kinase (MAPK) signaling pathways. In addition, heat shock proteins (HSP) 
      and other cofactors interact with HIF-1 subunits. HIF-1 increases the 
      transcription of several genes for proteins that promote blood flow and 
      inflammation, including vascular endothelial growth factor (VEGF), heme 
      oxygenase-1, endothelial and inducible nitric oxide synthase (NOS) and 
      cyclooxygenase-2 (COX-2). The pharmacologic activation of the HIF-1 complex can 
      be desirable in ischemic and inflammatory disorders. In contrast, HIF-1 blockade 
      may be beneficial to prevent tumor angiogenesis and tumor growth.
FAU - Hellwig-Burgel, Thomas
AU  - Hellwig-Burgel T
AD  - Institute of Physiology, University of Luebeck, D-23538 Luebeck, Germany.
FAU - Stiehl, Daniel P
AU  - Stiehl DP
FAU - Wagner, Anika E
AU  - Wagner AE
FAU - Metzen, Eric
AU  - Metzen E
FAU - Jelkmann, Wolfgang
AU  - Jelkmann W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Animals
MH  - Cytokines/immunology
MH  - DNA-Binding Proteins/*immunology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - MAP Kinase Signaling System/immunology
MH  - Nuclear Proteins/*immunology
MH  - Proteasome Endopeptidase Complex/immunology
MH  - Transcription Factors/*immunology
RF  - 166
EDAT- 2005/06/17 09:00
MHDA- 2005/09/09 09:00
CRDT- 2005/06/17 09:00
PHST- 2005/06/17 09:00 [pubmed]
PHST- 2005/09/09 09:00 [medline]
PHST- 2005/06/17 09:00 [entrez]
AID - 10.1089/jir.2005.25.297 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2005 Jun;25(6):297-310. doi: 10.1089/jir.2005.25.297.