PMID- 15958099
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20151113
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 12
IP  - 7
DP  - 2005 Jul
TI  - Myasthenia gravis accompanied by alopecia areata: clinical and immunogenetic 
      aspects.
PG  - 566-70
AB  - The purpose of this study was to evaluate the clinical characteristics of 
      patients who had both myasthenia gravis (MG) and alopecia areata (AA). Clinical 
      information was retrospectively collected for 159 Japanese patients with MG. 
      Human leukocyte antigen (HLA)-DQB1 and DRB1 alleles were determined by 
      genotyping. Of 159 MG patients, six (3.7%) developed AA after the onset of MG and 
      thymectomy. The prevalence of AA in MG patients was higher than that reported in 
      Caucasians. The frequencies of bulbar involvement, myasthenic crisis, and thymoma 
      were significantly higher in MG patients with AA than in those without (P = 
      0.007, 0.004, and 0.006, respectively). All but one patient with AA had advanced 
      stage thymoma. Three patients with a severe form of AA (alopecia totalis) had 
      additional autoimmune diseases: myocarditis, myositis, and pure red cell aplasia. 
      DRB1*0901 and DQB1*0303 tended to be more frequently detected in the six MG 
      patients with AA than in the 82 patients without it. In conclusion, a subset of 
      MG patients who have severe neuromuscular symptoms and thymoma develop AA several 
      years after thymectomy.
FAU - Suzuki, S
AU  - Suzuki S
AD  - Department of Neurology, Keio University School of Medicine, Shinanomachi, Tokyo, 
      Japan.
FAU - Shimoda, M
AU  - Shimoda M
FAU - Kawamura, M
AU  - Kawamura M
FAU - Sato, H
AU  - Sato H
FAU - Nogawa, S
AU  - Nogawa S
FAU - Tanaka, K
AU  - Tanaka K
FAU - Suzuki, N
AU  - Suzuki N
FAU - Kuwana, M
AU  - Kuwana M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Alopecia Areata/*complications/epidemiology/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunogenetics
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*complications/immunology/physiopathology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Thymectomy
MH  - Thymoma/etiology/surgery
EDAT- 2005/06/17 09:00
MHDA- 2005/08/12 09:00
CRDT- 2005/06/17 09:00
PHST- 2005/06/17 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/06/17 09:00 [entrez]
AID - ENE1002 [pii]
AID - 10.1111/j.1468-1331.2005.01002.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2005 Jul;12(7):566-70. doi: 10.1111/j.1468-1331.2005.01002.x.