PMID- 15958261
OWN - NLM
STAT- MEDLINE
DCOM- 20051024
LR  - 20221207
IS  - 1472-9792 (Print)
IS  - 1472-9792 (Linking)
VI  - 85
IP  - 4
DP  - 2005 Jul
TI  - Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report.
PG  - 259-67
AB  - Analysis of correlation between tuberculosis (TB) and human leukocyte antigen 
      (HLA) in populations from Asia and Latin America has shown conflicting results. 
      The aim of this study was to evaluate the frequency of HLA-DRB1-DQB1 two-locus 
      haplotypes of 61 TB patients and 125 healthy volunteers in the same ethnic group 
      in Poland. DRB1 and DQB1 alleles were determined by PCR-SSP "low-resolution" and 
      "high-resolution" methods. Our study showed that DRB1*1601 and DQB1*0502 alleles 
      were more frequent, whereas DQB1*0201 was rarer in TB than in controls. 
      DRB1*16-DQB1*05, DRB1*04-DQB1*03 and DRB1*1601-DQB1*0502 haplotype were more 
      common, and DRB1*11-DQB1*03 less frequent in TB in comparison to controls. 
      Positive linkage disequilibrium (LD) for DRB1*01-DQB1*05, DRB1*03-DQB1*02, 
      DRB1*11-DQB1*03, DRB1*13-DQB1*06 and DRB1*15-DQB1*06 was found in controls. A 
      trend towards the positive LD for DRB1*01-DQB1*05, DRB1*03-DQB1*02, 
      DRB1*11-DQB1*03, DRB1*15-DQB1*06 and DRB1*16-DQB1*05 was shown in TB. The trend 
      towards the positive LD for DRB1*16-DQB1*05 haplotype in TB patients was not 
      observed in the control group. It seems likely that the presence of DRB1*1601, 
      DQB1*0502 alleles and DRB1*1601-DQB1*0502, DRB1*04-DQB1*03, DRB1*14-DQB1*05 
      haplotypes may be related to a higher risk of developing TB, whereas low 
      frequency of DQB1*0201 and DRB1*11-DQB1*03 haplotype may be linked to the 
      resistance to TB.
FAU - Dubaniewicz, Anna
AU  - Dubaniewicz A
AD  - Department of Pathophysiology, Medical University of Gdansk, 80-211 Gdansk, 
      Debinki 7 Str., Poland. aduban@amg.gda.pl
FAU - Moszkowska, Grazyna
AU  - Moszkowska G
FAU - Szczerkowska, Zofia
AU  - Szczerkowska Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050323
PL  - Scotland
TA  - Tuberculosis (Edinb)
JT  - Tuberculosis (Edinburgh, Scotland)
JID - 100971555
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/*genetics
MH  - Poland/ethnology
MH  - Tuberculosis, Pulmonary/*genetics
MH  - White People/*genetics
EDAT- 2005/06/17 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/06/17 09:00
PHST- 2004/07/28 00:00 [received]
PHST- 2004/12/12 00:00 [revised]
PHST- 2004/12/16 00:00 [accepted]
PHST- 2005/06/17 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/06/17 09:00 [entrez]
AID - S1472-9792(05)00014-4 [pii]
AID - 10.1016/j.tube.2004.12.003 [doi]
PST - ppublish
SO  - Tuberculosis (Edinb). 2005 Jul;85(4):259-67. doi: 10.1016/j.tube.2004.12.003. 
      Epub 2005 Mar 23.