PMID- 15962273
OWN - NLM
STAT- MEDLINE
DCOM- 20051108
LR  - 20151119
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 32
IP  - 4
DP  - 2005 Oct
TI  - Production of monocyte chemoattractant protein-1 in amyotrophic lateral 
      sclerosis.
PG  - 541-4
AB  - The presence of activated microglia in the spinal cord of amyotrophic lateral 
      sclerosis (ALS) patients is usually accompanied by inflammatory biochemical 
      changes, but these are largely unexplored. Monocyte chemoattractant protein-1 
      (MCP-1) is critical for recruitment of inflammatory cells of monocytic lineage 
      after inflammation or injury to the central nervous system. MCP-1 concentrations 
      were measured by an enzyme-linked immunosorbent assay in the cerebrospinal fluid 
      (CSF) and the serum of 27 patients with ALS and 30 patients with noninflammatory 
      neurological diseases. In ALS, circulating MCP-1 levels were significantly 
      increased in the serum and particularly in the CSF. Immunoreactivity for MCP-1 in 
      ALS spinal cord was detected mostly in astrocytes but also in microglia, neurons, 
      and within the vasculature of the cord. Our findings suggest a role for MCP-1 as 
      an important molecular mediator of the injury response in ALS.
CI  - Muscle Nerve, 2005.
FAU - Baron, Pierluigi
AU  - Baron P
AD  - Department of Neurological Sciences, Dino Ferrari Center, University of Milan 
      Medical School, IRCCS Ospedale Maggiore Policlinico, Via S. Sforza 35, 20122 
      Milan, Italy. pierluigi.baron@unimi.it
FAU - Bussini, Simona
AU  - Bussini S
FAU - Cardin, Veronica
AU  - Cardin V
FAU - Corbo, Massimo
AU  - Corbo M
FAU - Conti, Giancarlo
AU  - Conti G
FAU - Galimberti, Daniela
AU  - Galimberti D
FAU - Scarpini, Elio
AU  - Scarpini E
FAU - Bresolin, Nereo
AU  - Bresolin N
FAU - Wharton, Stephen B
AU  - Wharton SB
FAU - Shaw, Pamela J
AU  - Shaw PJ
FAU - Silani, Vincenzo
AU  - Silani V
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/*metabolism/pathology
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Chemokine CCL2/*biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Microglia/metabolism/pathology
MH  - Middle Aged
MH  - Neurons/metabolism/pathology
MH  - Severity of Illness Index
MH  - Spinal Cord/metabolism/pathology
EDAT- 2005/06/18 09:00
MHDA- 2005/11/09 09:00
CRDT- 2005/06/18 09:00
PHST- 2005/06/18 09:00 [pubmed]
PHST- 2005/11/09 09:00 [medline]
PHST- 2005/06/18 09:00 [entrez]
AID - 10.1002/mus.20376 [doi]
PST - ppublish
SO  - Muscle Nerve. 2005 Oct;32(4):541-4. doi: 10.1002/mus.20376.