PMID- 15962374
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20211203
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 23
DP  - 2005 Jun 21
TI  - A comparison of the clinical, demographic and psychiatric profiles among patients 
      with erosive and non-erosive reflux disease in a multi-ethnic Asian country.
PG  - 3558-61
AB  - AIM: To examine the clinical spectrum of gastroesophageal reflux disease (GERD) 
      and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, 
      demographic and psychiatric profiles. METHODS: Patients with reflux symptoms were 
      enrolled and stratified to NERD and ERD after endoscopy (LA classification). 
      Patients with ERD presenting with dyspepsia were included. Patients on proton 
      pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. 
      Demographic data, Helicobacter pylori (H pylori) status and presence of minor 
      psychiatric morbidity (based on General Health Questionnaire-28) were analyzed. 
      RESULTS: Among 690 patients screened, 533 were eligible for analysis (male to 
      female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum 
      of GERD: N: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. 
      Compared to patients with NERD, patients with ERD were significantly older (45 vs 
      39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 
      9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were 
      more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a 
      higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not 
      significant. On multivariate analysis, age and presence of minor psychiatric 
      morbidity remained with significant differences. CONCLUSION: The majority of 
      patients who have typical symptoms of GERD have NERD or mild erosive reflux 
      disease. Compared to patients with erosive reflux disease, patients with NERD 
      were younger and had a higher prevalence of minor psychiatric morbidity.
FAU - Ang, Tiing-Leong
AU  - Ang TL
AD  - Division of Gastroenterology, Department of Medicine, Changi General Hospital, 2 
      Simei Street 3, 529889, Singapore. tiing_leong_ang@cgh.com.sg
FAU - Fock, Kwong-Ming
AU  - Fock KM
FAU - Ng, Tay-Meng
AU  - Ng TM
FAU - Teo, Eng-Kiong
AU  - Teo EK
FAU - Chua, Tju-Siang
AU  - Chua TS
FAU - Tan, Jessica
AU  - Tan J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Adult
MH  - Aged
MH  - Demography
MH  - *Ethnicity
MH  - Female
MH  - Gastroesophageal Reflux/*epidemiology/*physiopathology/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Singapore/epidemiology
PMC - PMC4315960
EDAT- 2005/06/18 09:00
MHDA- 2005/12/13 09:00
PMCR- 2005/06/21
CRDT- 2005/06/18 09:00
PHST- 2005/06/18 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/06/18 09:00 [entrez]
PHST- 2005/06/21 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i23.3558 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Jun 21;11(23):3558-61. doi: 10.3748/wjg.v11.i23.3558.