PMID- 15962390
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 23
DP  - 2005 Jun 21
TI  - Relationship between the downregulation of HLA class I antigen and 
      clinicopathological significance in gastric cancer.
PG  - 3628-31
AB  - AIM: To discuss the expression of human leukocyte antigen (HLA) class I antigens 
      in gastric cancer and correlate these with pathologic type and TNM stage. 
      METHODS: The expression of HLA class I antigen was detected by 
      immunohistochemistry in 185 specimens of gastric cancer, 20 gastric cancer 
      specimens with lymphatic metastasis and 22 controls of normal gastric mucosa 
      using four monoclonal antibodies. RESULTS: The expression of HLA class I antigen 
      (B/C locus) was significantly downregulated in gastric cancer and in lymphatic 
      metastasis than that in normal gastric mucosa (chi2=7.712, P<0.05). The 
      expression of other HLA class I antigens was also downregulated, but the change 
      was slight. There was no relationship between the downregulation of HLA class I 
      antigen and that of beta2m and LMP2. The expression of HLA class I (B/C locus) 
      was statistically correlated with pathologic stage in gastric adenocarcinoma 
      (chi2=4.164, P<0.05). CONCLUSION: The expression of HLA class I antigen (B/C 
      locus) was obviously downregulated in gastric cancer and in lymphatic metastasis. 
      This abnormal expression would provide the tumor cells with a way to avoid 
      immunological recognition.
FAU - Shen, Yu-Qing
AU  - Shen YQ
AD  - State Education Ministry Laboratory of Development Genes and Human Diseases, 
      Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu 
      Province, China.
FAU - Zhang, Jian-Qiong
AU  - Zhang JQ
FAU - Miao, Feng-Qing
AU  - Miao FQ
FAU - Zhang, Jian-Min
AU  - Zhang JM
FAU - Jiang, Qin
AU  - Jiang Q
FAU - Chen, Hao
AU  - Chen H
FAU - Shan, Xiang-Nian
AU  - Shan XN
FAU - Xie, Wei
AU  - Xie W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gastric Mucosa/cytology/immunology
MH  - Gene Expression Regulation, Neoplastic/immunology
MH  - HLA Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis/immunology
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Stomach Neoplasms/*genetics/*immunology/pathology
PMC - PMC4315976
EDAT- 2005/06/18 09:00
MHDA- 2005/12/13 09:00
PMCR- 2005/06/21
CRDT- 2005/06/18 09:00
PHST- 2005/06/18 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/06/18 09:00 [entrez]
PHST- 2005/06/21 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i23.3628 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Jun 21;11(23):3628-31. doi: 10.3748/wjg.v11.i23.3628.