PMID- 15962714
OWN - NLM
STAT- MEDLINE
DCOM- 20050728
LR  - 20191026
IS  - 0190-2148 (Print)
IS  - 0190-2148 (Linking)
VI  - 31
IP  - 3
DP  - 2005 Apr
TI  - Double-stranded RNA stimulates the expression of monocyte chemoattractant 
      protein-1 in BEAS-2B bronchial epithelial cells.
PG  - 361-75
AB  - BEAS-2B bronchial epithelial cells were treated with polyinosinic-polycytidylic 
      acid (poly IC), a synthetic double-stranded RNA (dsRNA) analog, and the 
      expressions of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein were 
      analyzed by reverse transcriptase-polymerase chain reaction and enzyme-linked 
      immunosorbent assay. Poly IC enhanced the expression of MCP-1 and release of 
      mononuclear cell chemotactic activity, which were inhibited by dexamethasone 
      pre-treatment. The poly IC-induced up-regulation of MCP-1 was blocked by 
      2-aminopurine, a specific inhibitor of dsRNA-dependent protein kinase, but not by 
      nuclear factor (NF)-kappaB inhibitor SN50.
FAU - Taima, Kageaki
AU  - Taima K
AD  - The Second Department of Internal Medicine, Hirosaki University School of 
      Medicine, Hirosaki, Japan.
FAU - Takanashi, Shingo
AU  - Takanashi S
FAU - Okumura, Ken
AU  - Okumura K
FAU - Imaizumi, Tadaatsu
AU  - Imaizumi T
FAU - Kumagai, Mika
AU  - Kumagai M
FAU - Ishikawa, Akira
AU  - Ishikawa A
FAU - Yoshida, Hidemi
AU  - Yoshida H
FAU - Satoh, Kei
AU  - Satoh K
FAU - Fujita, Takashi
AU  - Fujita T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Double-Stranded)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptors)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Base Sequence
MH  - Bronchi/*drug effects/*metabolism
MH  - Cell Line
MH  - Chemokine CCL2/*genetics/*metabolism
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Culture Media, Conditioned
MH  - DNA, Complementary/genetics
MH  - Dexamethasone/pharmacology
MH  - Epithelial Cells/drug effects/metabolism
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Membrane Glycoproteins/genetics
MH  - Monocytes/drug effects/physiology
MH  - Poly I-C/pharmacology
MH  - RNA, Double-Stranded/*pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Cell Surface/genetics
MH  - Toll-Like Receptors
EDAT- 2005/06/21 09:00
MHDA- 2005/07/29 09:00
CRDT- 2005/06/21 09:00
PHST- 2005/06/21 09:00 [pubmed]
PHST- 2005/07/29 09:00 [medline]
PHST- 2005/06/21 09:00 [entrez]
AID - 10.1080/01902140590918885 [doi]
PST - ppublish
SO  - Exp Lung Res. 2005 Apr;31(3):361-75. doi: 10.1080/01902140590918885.