PMID- 15963035
OWN - NLM
STAT- MEDLINE
DCOM- 20050929
LR  - 20220330
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 6
IP  - 2
DP  - 2005 Jun
TI  - Neuropsychiatric disorders at the presentation of type 2 diabetes mellitus in 
      children.
PG  - 84-9
AB  - OBJECTIVES: To estimate the frequency of neuropsychiatric disease (NPD) in an 
      urban pediatric type 2 diabetes mellitus (T2DM) population, to compare 
      demographic characteristics of affected patients with those unaffected with NPD, 
      and to determine the frequency of psychotropic medication treatment. STUDY 
      DESIGN: Retrospective chart review of patients with T2DM at the Children's 
      Hospital of Philadelphia. RESULTS: Of 237 patients with T2DM, 46 (19.4%) were 
      found to have NPD at the presentation of diabetes. Diagnoses by report included 
      depression, attention-deficit hyperactivity disorder (ADHD), neurodevelopmental 
      disorders, schizophrenia, and bipolar disorder. Those affected were 63% females 
      and 37% males, with a mean age of 14.6 yr and body mass index (BMI) of 34.3 
      kg/m(2) at diagnosis of T2DM. Patients were 79% African American, 13% Caucasian, 
      4.3% Hispanic, and 4.3% Asian. There were no statistically significant 
      differences in demographic characteristics or BMI between those affected and 
      unaffected with NPD. Twenty-nine patients (63%) were on psychotropic medication 
      and were prescribed 58 medications, most commonly mood stabilizers (n = 20) and 
      atypical antipsychotics (n = 17). CONCLUSIONS: Our data reveal a high frequency 
      of NPD among pediatric patients with T2DM at presentation to a tertiary care, 
      urban medical center. Many affected patients are receiving psychotropic 
      medication. These data have implications for screening regimens for pediatric 
      populations at high risk for T2DM and for therapeutic interventions, including 
      lifestyle measures.
FAU - Levitt Katz, Lorraine E
AU  - Levitt Katz LE
AD  - Division of Endocrinology, The Children's Hospital of Philadelphia, PA 
      19104-4399, USA. katzl@email.chop.edu
FAU - Swami, Sanjeev
AU  - Swami S
FAU - Abraham, Maire
AU  - Abraham M
FAU - Murphy, Kathryn M
AU  - Murphy KM
FAU - Jawad, Abbas F
AU  - Jawad AF
FAU - McKnight-Menci, Heather
AU  - McKnight-Menci H
FAU - Berkowitz, Robert
AU  - Berkowitz R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
SB  - IM
MH  - Adolescent
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mental Disorders/complications/*epidemiology
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - United States/epidemiology
EDAT- 2005/06/21 09:00
MHDA- 2005/09/30 09:00
CRDT- 2005/06/21 09:00
PHST- 2005/06/21 09:00 [pubmed]
PHST- 2005/09/30 09:00 [medline]
PHST- 2005/06/21 09:00 [entrez]
AID - PDI105 [pii]
AID - 10.1111/j.1399-543X.2005.00105.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2005 Jun;6(2):84-9. doi: 10.1111/j.1399-543X.2005.00105.x.