PMID- 15964402
OWN - NLM
STAT- MEDLINE
DCOM- 20051025
LR  - 20111117
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 37
IP  - 5
DP  - 2005 Jun
TI  - Human leukocyte antigen allelic groups and haplotypes in a brazilian sample of 
      volunteer donors for bone marrow transplant in Curitiba, Parana, Brazil.
PG  - 2293-6
AB  - Bone Marrow Transplant (BMT) is a lifesaving procedure for several diseases. 
      Histocompatibility between host and donor is crucial for the success of this 
      therapy. Since human leukocyte antigen (HLA) genes are the most polymorphic in 
      humans, a foreknowledge of their frequencies and a vast register of volunteer 
      donors are important for patients who need an unrelated donor. This research 
      evaluated data from 3500 HLA-typed donors using PCR-SSP (One Lambda ABDRX kits, 
      low/medium resolution). The allele and haplotype frequencies were calculated from 
      the donor HLA typings. Among the total sample we observed that the allelic groups 
      HLA-A*02, -B*35, and -DRB1*11 had frequencies of 0.228, 0.112, and 0.125, 
      respectively. The haplotype HLA-A*01-B*08-DRB1*03 was the most frequent (0.024). 
      We also compared our results with another study conducted in a Northeastern 
      Brazilian population. The identification of the most common allelic groups and 
      haplotypes is of great interest, not only to know the HLA composition of the 
      population but also to search for the best HLA match for a transplant. However, 
      the search for the perfect match depends on the eventual registration of every 
      specific donor in the national registers for bone marrow donation.
FAU - Ruiz, T M
AU  - Ruiz TM
AD  - Histocompatibility and Immunogenetics Laboratory (LIGH), Department of Genetics, 
      UFPR, Sala 31, Jardim das Americas, Curitiba-PR, Brazil, CEP 81530-990.
FAU - da Costa, S M C M
AU  - da Costa SM
FAU - Ribas, F
AU  - Ribas F
FAU - Luz, P R
AU  - Luz PR
FAU - Lima, S S
AU  - Lima SS
FAU - da Graca Bicalho, M
AU  - da Graca Bicalho M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Bone Marrow Transplantation/*immunology
MH  - Brazil
MH  - HLA Antigens/*genetics/*immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Living Donors
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
EDAT- 2005/06/21 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/06/21 09:00
PHST- 2004/12/17 00:00 [received]
PHST- 2005/06/21 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/06/21 09:00 [entrez]
AID - S0041-1345(05)00273-3 [pii]
AID - 10.1016/j.transproceed.2005.03.036 [doi]
PST - ppublish
SO  - Transplant Proc. 2005 Jun;37(5):2293-6. doi: 10.1016/j.transproceed.2005.03.036.