PMID- 15967634
OWN - NLM
STAT- MEDLINE
DCOM- 20060929
LR  - 20061115
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 20
IP  - 4
DP  - 2005 Nov-Dec
TI  - Teratogenic effects of diphenyl diselenide in Wistar rats.
PG  - 561-8
AB  - Diphenyl diselenide is an organoselenium compound with potential therapeutic use. 
      The present study evaluates the effects of single maternal subcutaneous injection 
      of 50 and 100mg/kg diphenyl diselenide [(PhSe)2] at gestational days (GD) 6, 10 
      or 17 in Wistar rats. The highest dose of (PhSe2 was also administered at GD 
      7-12. External and internal fetal soft-tissue examination was performed at GD 20. 
      No mortality was observed in fetuses or dams at any (PhSe)2 treatment group. 
      Neither did exposure to (PhSe)2 cause significant changes to fetal body weight, 
      organ weight, or fetal size when administered at GD 6-8, 10-12 or 17. Exposure to 
      100mg/kg (PhSe)2 at GD 9 produced significant changes in fetal biometry 
      (crown-rump (CR) length) and body weight. No significant increase in the 
      proportion of fetuses with external visible abnormalities was observed in groups 
      exposed to (PhSe)2. Skeletal anomalies were observed in fetuses in the GD 9-11 
      treatment groups and included incomplete ossification of cranial bones, misshapen 
      and incomplete ossification of sternebrae, reduced sternebrae number, wavy and 
      extra ribs, incomplete ossification of fore and hindpaw bones and incomplete 
      ossification of sacral and caudal bones. We conclude that maternal administration 
      of (PhSe)2 during GD 7-12 led to increased incidences of these skeletal 
      variations or anomalies, but did not cause externally visible malformations in 
      rat fetuses.
FAU - Favero, Alexandre M
AU  - Favero AM
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria, SM, RS, CEP 97105-900 Santa Maria, Brazil.
FAU - Weis, Simone N
AU  - Weis SN
FAU - Stangherlin, Eluza C
AU  - Stangherlin EC
FAU - Zeni, Gilson
AU  - Zeni G
FAU - Rocha, Joao B T
AU  - Rocha JB
FAU - Nogueira, Cristina W
AU  - Nogueira CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050620
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Antioxidants)
RN  - 0 (Benzene Derivatives)
RN  - 0 (Organoselenium Compounds)
RN  - 1666-13-3 (diphenyldiselenide)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Animals
MH  - Antioxidants/administration & dosage/*toxicity
MH  - Benzene Derivatives/administration & dosage/*toxicity
MH  - Bone and Bones/abnormalities
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetal Growth Retardation/chemically induced
MH  - Fetus/drug effects
MH  - Gestational Age
MH  - Limb Deformities, Congenital/pathology
MH  - Maternal-Fetal Exchange
MH  - Organoselenium Compounds/administration & dosage/*toxicity
MH  - Osteogenesis/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
EDAT- 2005/06/22 09:00
MHDA- 2006/09/30 09:00
CRDT- 2005/06/22 09:00
PHST- 2005/02/10 00:00 [received]
PHST- 2005/04/06 00:00 [revised]
PHST- 2005/04/30 00:00 [accepted]
PHST- 2005/06/22 09:00 [pubmed]
PHST- 2006/09/30 09:00 [medline]
PHST- 2005/06/22 09:00 [entrez]
AID - S0890-6238(05)00115-2 [pii]
AID - 10.1016/j.reprotox.2005.04.013 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2005 Nov-Dec;20(4):561-8. doi: 10.1016/j.reprotox.2005.04.013. 
      Epub 2005 Jun 20.