PMID- 15968268
OWN - NLM
STAT- MEDLINE
DCOM- 20051110
LR  - 20061115
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 53
IP  - 1 Suppl 1
DP  - 2005 Jul
TI  - Atopic dermatitis.
PG  - S86-93
AB  - Atopic dermatitis (AD) is commonly associated with immunoglobulin E (IgE) 
      antibody-related mechanisms, which are the focus of this article. The vast 
      majority of patients with AD exhibit hyperproduction of IgE, particularly during 
      disease onset or flare. IgE-dependent late-phase reactions may influence the 
      chronic inflammatory response in AD. Clearly, genetics plays a major role in 
      determining who develops AD. However, the recent increase in AD prevalence 
      suggests that a complex interaction between environmental factors and 
      susceptibility genes results in clinical expression of the disorder. These 
      immunologic "triggers" differ among individuals and include various foods, 
      airborne allergens, irritants and contactants, hormones, stress, climate, and 
      microorganisms. Although much about AD remains to be elucidated, our current 
      understanding of its pathophysiology has provided clinicians with the ability to 
      construct more rational therapeutic interventions, including multiple-agent 
      regimens that provide both immediate relief and effective long-term management. 
      Future advances will come from identification of the genes causing this disease 
      and further elucidation of the immunoregulatory mechanisms involved in the 
      pathogenesis of AD.
FAU - Abramovits, William
AU  - Abramovits W
AD  - Texas Dermatology Associates, Dallas, TX 75230, USA. waresearch@texasderm.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antigen-Presenting Cells/immunology
MH  - Child
MH  - Comorbidity
MH  - *Dermatitis, Atopic/epidemiology/genetics/immunology/pathology
MH  - Diseases in Twins/epidemiology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/genetics
MH  - Immunoglobulin E/immunology
MH  - Keratinocytes/immunology
MH  - Lymphocyte Subsets/immunology
MH  - Macrophages/immunology
MH  - Monocytes/immunology
MH  - Prevalence
RF  - 72
EDAT- 2005/06/22 09:00
MHDA- 2005/11/11 09:00
CRDT- 2005/06/22 09:00
PHST- 2005/06/22 09:00 [pubmed]
PHST- 2005/11/11 09:00 [medline]
PHST- 2005/06/22 09:00 [entrez]
AID - S0190962205013125 [pii]
AID - 10.1016/j.jaad.2005.04.034 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2005 Jul;53(1 Suppl 1):S86-93. doi: 
      10.1016/j.jaad.2005.04.034.