PMID- 15970378
OWN - NLM
STAT- MEDLINE
DCOM- 20050906
LR  - 20220318
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 385
IP  - 3
DP  - 2005 Sep 16
TI  - Protective effect of melatonin against head trauma-induced hippocampal damage and 
      spatial memory deficits in immature rats.
PG  - 234-9
AB  - It is well known that head trauma induces the cognitive dysfunction resulted from 
      hippocampal damage. In the present study, we aimed to demonstrate the effect of 
      melatonin on hippocampal damage and spatial memory deficits in 7-day-old rat pups 
      subjected to contusion injury. Melatonin was injected intraperitoneally at the 
      doses of 5 or 20 mg/kg of body weight immediately after induction of traumatic 
      injury. Hippocampal damage was examined by cresyl violet staining and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. 
      Spatial memory performance was assessed in the Morris water maze. Melatonin 
      significantly attenuated trauma-induced neuronal death in hippocampal CA1, CA3 
      regions and dentate gyrus, and improved spatial memory deficits, which was 
      equally effective at doses of 5-20 mg/kg. The present results suggest that 
      melatonin is a highly promising agent for preventing the unfavorable outcomes of 
      traumatic brain injury in young children.
FAU - Ozdemir, Durgul
AU  - Ozdemir D
AD  - Department of Pediatrics, School of Medicine, Dokuz Eylul University, Inciralti, 
      35340 Izmir, Turkey.
FAU - Tugyan, Kazim
AU  - Tugyan K
FAU - Uysal, Nazan
AU  - Uysal N
FAU - Sonmez, Ulker
AU  - Sonmez U
FAU - Sonmez, Atac
AU  - Sonmez A
FAU - Acikgoz, Osman
AU  - Acikgoz O
FAU - Ozdemir, Nail
AU  - Ozdemir N
FAU - Duman, Murat
AU  - Duman M
FAU - Ozkan, Hasan
AU  - Ozkan H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Neuroprotective Agents)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Brain Injuries/complications/*drug therapy
MH  - Hippocampus/*drug effects
MH  - In Situ Nick-End Labeling
MH  - Maze Learning/drug effects
MH  - Melatonin/*pharmacology
MH  - Memory Disorders/etiology/*prevention & control
MH  - Neurons/drug effects/pathology
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2005/06/23 09:00
MHDA- 2005/09/07 09:00
CRDT- 2005/06/23 09:00
PHST- 2005/04/12 00:00 [received]
PHST- 2005/05/15 00:00 [revised]
PHST- 2005/05/16 00:00 [accepted]
PHST- 2005/06/23 09:00 [pubmed]
PHST- 2005/09/07 09:00 [medline]
PHST- 2005/06/23 09:00 [entrez]
AID - S0304-3940(05)00608-7 [pii]
AID - 10.1016/j.neulet.2005.05.055 [doi]
PST - ppublish
SO  - Neurosci Lett. 2005 Sep 16;385(3):234-9. doi: 10.1016/j.neulet.2005.05.055.