PMID- 15972660
OWN - NLM
STAT- MEDLINE
DCOM- 20050831
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 175
IP  - 1
DP  - 2005 Jul 1
TI  - TLR-dependent activation stimuli associated with Th1 responses confer NK cell 
      stimulatory capacity to mouse dendritic cells.
PG  - 286-92
AB  - Dendritic cells (DCs) have an important role in the activation of NK cells that 
      exert direct antitumor and antimicrobial effects and can influence the 
      development of adaptive T cell responses. DCs acquire NK cell stimulatory 
      capacity after exposure to various stimuli. In this study we investigated the 
      nature of the stimuli that confer to DCs the NK cell-activating capacity. After 
      exposure of DCs to TLR-dependent and -independent microbial stimuli and to 
      nonmicrobial stimuli, we evaluated the ability of activated DCs to elicit 
      IFN-gamma production from NK cells in vitro and to promote NK cell activation in 
      vivo. We show in this study that only TLR-dependent microbial stimuli typically 
      associated with Th1 responses confer to DCs the ability to activate NK cells, 
      whereas stimuli associated with Th2 responses do not have this property.
FAU - Zanoni, Ivan
AU  - Zanoni I
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, 
      Italy.
FAU - Foti, Maria
AU  - Foti M
FAU - Ricciardi-Castagnoli, Paola
AU  - Ricciardi-Castagnoli P
FAU - Granucci, Francesca
AU  - Granucci F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Lipoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptors)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 87420-41-5 (2,3-bis(palmitoyloxy)-2-propyl-1-palmitoylcysteine)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Animals
MH  - Coculture Techniques
MH  - CpG Islands/immunology
MH  - Cysteine/analogs & derivatives/pharmacology
MH  - Dendritic Cells/drug effects/*immunology
MH  - Interferon-gamma/biosynthesis
MH  - Killer Cells, Natural/*immunology
MH  - Leishmania mexicana/immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Lipoproteins/pharmacology
MH  - Lymphocyte Activation
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mycobacterium bovis/immunology
MH  - Receptors, Cell Surface/*metabolism
MH  - Th1 Cells/*immunology
MH  - Toll-Like Receptors
EDAT- 2005/06/24 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/06/24 09:00
PHST- 2005/06/24 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/06/24 09:00 [entrez]
AID - 175/1/286 [pii]
AID - 10.4049/jimmunol.175.1.286 [doi]
PST - ppublish
SO  - J Immunol. 2005 Jul 1;175(1):286-92. doi: 10.4049/jimmunol.175.1.286.