PMID- 15974627
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20240312
IS  - 0163-3864 (Print)
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 68
IP  - 6
DP  - 2005 Jun
TI  - Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline 
      inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.
PG  - 947-50
AB  - Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible 
      factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 
      0.2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both 
      hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha 
      protein accumulation.
FAU - Zhou, Yu-Dong
AU  - Zhou YD
AD  - National Center for Natural Products Research and Department of Pharmacognosy, 
      Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of 
      Mississippi, University, 38677, USA.
FAU - Kim, Yong-Pil
AU  - Kim YP
FAU - Mohammed, Kaleem Asjad
AU  - Mohammed KA
FAU - Jones, Deborah K
AU  - Jones DK
FAU - Muhammad, Ilias
AU  - Muhammad I
FAU - Dunbar, D Chuck
AU  - Dunbar DC
FAU - Nagle, Dale G
AU  - Nagle DG
LA  - eng
GR  - R01 CA098787/CA/NCI NIH HHS/United States
GR  - R56 CA098787/CA/NCI NIH HHS/United States
GR  - R01 CA098787-02/CA/NCI NIH HHS/United States
GR  - R01 CA098787-01A2/CA/NCI NIH HHS/United States
GR  - CA-98787-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Alkaloids)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Quinazolines)
RN  - 0 (Terpenes)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 0 (Transcription Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (isocephaeline)
RN  - 0 (klugine)
RN  - X8D5EPO80M (Emetine)
SB  - IM
MH  - Alkaloids/*chemistry/*pharmacology
MH  - Breast Neoplasms
MH  - DNA-Binding Proteins/*drug effects
MH  - Emetine/*chemistry/*pharmacology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Molecular Structure
MH  - Nuclear Proteins/*drug effects
MH  - Quinazolines/*chemistry/*pharmacology
MH  - Rubiaceae/chemistry
MH  - Terpenes/*chemistry/*pharmacology
MH  - Tetrahydroisoquinolines/*chemistry/*pharmacology
MH  - Transcription Factors/*drug effects
MH  - Tumor Cells, Cultured
MH  - Vascular Endothelial Growth Factor A/analysis
PMC - PMC2907142
MID - NIHMS216827
EDAT- 2005/06/25 09:00
MHDA- 2005/08/12 09:00
PMCR- 2010/07/20
CRDT- 2005/06/25 09:00
PHST- 2005/06/25 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/06/25 09:00 [entrez]
PHST- 2010/07/20 00:00 [pmc-release]
AID - 10.1021/np050029m [doi]
PST - ppublish
SO  - J Nat Prod. 2005 Jun;68(6):947-50. doi: 10.1021/np050029m.