PMID- 15975736
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20151119
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 81
IP  - 1
DP  - 2006 Jan 4
TI  - Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in 
      humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine 
      and placebo.
PG  - 27-36
AB  - In animals, two-choice drug discrimination studies have demonstrated that the 
      behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) are mediated by 
      dopaminergic and serotonergic systems. In order to delineate the relative role of 
      these systems, three-choice paradigms have been used in animals, with findings 
      indicating a more prominent role for serotonin. Human studies assessing the 
      subjective and physiological effects of MDMA have also indicated a mixed action. 
      To parallel animal studies, the participants in the present study were trained to 
      discriminate among a prototypic dopaminergic agonist, d-amphetamine, a prototypic 
      serotonergic agonist, meta-chlorophenylpiperazine (mCPP) and placebo and then 
      were tested with two doses of MDMA. In addition, subjective and physiological 
      effects were measured. The results demonstrated that humans could be trained to 
      discriminate among 20 mg d-amphetamine, 0.75 mg/kg mCPP and placebo. When tested 
      with 1.0 and 1.5 mg/kg, half the participants reported MDMA to be like 
      amphetamine and half like mCPP. There were no clear differences between these two 
      groups in other dimensions, although there was an indication that the individuals 
      who discriminated MDMA as d-amphetamine were more sensitive to the effects of all 
      the drugs. The subjective effects of all three drugs overlapped, although the 
      effects of MDMA appeared more amphetamine-like.
FAU - Johanson, Chris-Ellyn
AU  - Johanson CE
AD  - Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 
      Drug Abuse Research Division, 2761 East Jefferson, Detroit, MI 48207, USA. 
      cjohans@med.wayne.edu
FAU - Kilbey, Marlyne
AU  - Kilbey M
FAU - Gatchalian, Kristin
AU  - Gatchalian K
FAU - Tancer, Manuel
AU  - Tancer M
LA  - eng
GR  - K08 DA00370/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20050621
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Dopamine Agonists)
RN  - 0 (Hallucinogens)
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - REY0CNO998 (1-(3-chlorophenyl)piperazine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Adult
MH  - Alcoholism/diagnosis/psychology
MH  - Amphetamine-Related Disorders/diagnosis/*psychology
MH  - Arousal/*drug effects
MH  - *Dextroamphetamine
MH  - *Discrimination Learning
MH  - *Dopamine Agonists
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - *Hallucinogens
MH  - Humans
MH  - Male
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Piperazines
MH  - *Serotonin Agents
EDAT- 2005/06/25 09:00
MHDA- 2006/04/14 09:00
CRDT- 2005/06/25 09:00
PHST- 2005/02/21 00:00 [received]
PHST- 2005/05/04 00:00 [revised]
PHST- 2005/05/06 00:00 [accepted]
PHST- 2005/06/25 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2005/06/25 09:00 [entrez]
AID - S0376-8716(05)00162-6 [pii]
AID - 10.1016/j.drugalcdep.2005.05.003 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2006 Jan 4;81(1):27-36. doi: 
      10.1016/j.drugalcdep.2005.05.003. Epub 2005 Jun 21.