PMID- 15978556
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20071115
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1050
IP  - 1-2
DP  - 2005 Jul 19
TI  - Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term 
      depression in the CA1 region of the hippocampal slice.
PG  - 110-7
AB  - Prior synaptic or cellular activity influences degree or threshold for subsequent 
      induction of synaptic plasticity, a process known as metaplasticity. Thus, the 
      continual synaptic activity, spontaneous miniature excitatory synaptic current 
      (mEPSC) may correlate to the induction of long-term depression (LTD). Here, we 
      recorded whole-cell EPSC and mEPSC alternately in the Schaffer-CA1 synapses in 
      brain slice of young rats, and found that this recording configuration affected 
      neither EPSC nor mEPSC. Low frequency stimulation (LFS) induced variable 
      magnitudes of LTD. Remarkably, larger magnitudes of LTD were significantly 
      correlated to smaller amplitude/lower frequency of the basal mEPSC. Furthermore, 
      under the conditions reduced amplitude/frequency of the basal mEPSC by exposure 
      to behavioral stress immediately before slice preparation or low concentration of 
      calcium in bath solution, the magnitudes of LTD were still inversely correlated 
      to mEPSC amplitude/frequency. These new findings suggest that spontaneous mEPSC 
      may reflect functional and/or structural aspects of the synapses, the synaptic 
      history ongoing metaplasticity.
FAU - Zhang, Jichuan
AU  - Zhang J
AD  - Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese 
      Academy of Sciences, Kunming 650223, PR China.
FAU - Yang, Ya
AU  - Yang Y
FAU - Li, Hongbin
AU  - Li H
FAU - Cao, Jun
AU  - Cao J
FAU - Xu, Lin
AU  - Xu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Excitatory Postsynaptic Potentials/*physiology
MH  - Hippocampus/*physiology
MH  - Long-Term Synaptic Depression/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Organ Culture Techniques
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/physiology
EDAT- 2005/06/28 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/28 09:00
PHST- 2004/12/09 00:00 [received]
PHST- 2005/05/11 00:00 [revised]
PHST- 2005/05/13 00:00 [accepted]
PHST- 2005/06/28 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/28 09:00 [entrez]
AID - S0006-8993(05)00776-6 [pii]
AID - 10.1016/j.brainres.2005.05.032 [doi]
PST - ppublish
SO  - Brain Res. 2005 Jul 19;1050(1-2):110-7. doi: 10.1016/j.brainres.2005.05.032.