PMID- 15978559
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20071114
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1050
IP  - 1-2
DP  - 2005 Jul 19
TI  - Colocalization of CART with substance P but not enkephalin in the rat nucleus 
      accumbens.
PG  - 8-14
AB  - CART peptide is a novel neurotransmitter that, due to its distribution in the 
      brain and its modulation of dopamine systems, may be involved in aspects of 
      reward and drug abuse. In the nucleus accumbens (NAcc), CART peptide 
      immunoreactivity (IR) is colocalized with substance P-IR in neurons. 
      Approximately 86% of CART-IR cells colocalize with substance P, while only 19% of 
      substance P-IR neurons contain CART. CART peptide does not colocalize with 
      enkephalin-IR in this region. The substance P-CART colocalization exists in a 
      rostro-caudal gradient with more colocalization in rostral regions. The presence 
      of CART in substance P NAcc neurons suggests that CART neurons may be a subset of 
      the basal ganglia direct pathway or that CART neurons are involved in limbic 
      projections of the NAcc, such as to the ventral pallidum.
FAU - Hubert, George W
AU  - Hubert GW
AD  - Division of Neuroscience, Rm 3115 Yerkes National Research Center, 954 Gatewood 
      Road, Atlanta, GA 30329, USA. ghubert@emory.edu
FAU - Kuhar, Michael J
AU  - Kuhar MJ
LA  - eng
GR  - DA00418/DA/NIDA NIH HHS/United States
GR  - DA015040/DA/NIDA NIH HHS/United States
GR  - DA10732/DA/NIDA NIH HHS/United States
GR  - RR00165/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Enkephalins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Enkephalins/*metabolism
MH  - Fluorescent Antibody Technique
MH  - Male
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neural Pathways
MH  - Neurons/metabolism
MH  - Nucleus Accumbens/cytology/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substance P/*metabolism
EDAT- 2005/06/28 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/28 09:00
PHST- 2005/03/01 00:00 [received]
PHST- 2005/04/29 00:00 [revised]
PHST- 2005/05/03 00:00 [accepted]
PHST- 2005/06/28 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/28 09:00 [entrez]
AID - S0006-8993(05)00725-0 [pii]
AID - 10.1016/j.brainres.2005.05.025 [doi]
PST - ppublish
SO  - Brain Res. 2005 Jul 19;1050(1-2):8-14. doi: 10.1016/j.brainres.2005.05.025.