PMID- 15979455
OWN - NLM
STAT- MEDLINE
DCOM- 20050802
LR  - 20151119
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 96
IP  - 1
DP  - 2005 Jul 1
TI  - Effect of transdermal hormone replacement therapy on the monocyte chemoattractant 
      protein-1 concentrations and other vascular inflammatory markers and on 
      endothelial function in postmenopausal women.
PG  - 148-53
AB  - Monocyte chemoattractant protein-1 (MCP-1) is related to the progression of 
      atherosclerosis. However, little is known about the effects of transdermal 
      hormone replacement therapy (HRT) on circulating MCP-1, vascular inflammatory 
      marker concentrations, and endothelial function in postmenopausal women. The 
      effects of transdermal HRT on circulating MCP-1, vascular inflammatory marker 
      concentrations, and endothelium-dependent vasodilation were investigated in 
      postmenopausal women. Thirty-three women received transdermal HRT (continuous 
      17-beta estradiol patch 36 microg/day plus cyclic oral medroxyprogesterone 
      acetate 2.5 mg/day for 12 days/month) for 12 months, and 27 control patients did 
      not. Brachial artery flow-mediated vasodilation (FMD), assessed by ultrasound, 
      and circulating MCP-1 and vascular inflammatory marker (C-reactive protein, 
      intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 
      [VCAM-1], and E-selectin) concentrations were measured before and after 12 months 
      of treatment. In the HRT group, MCP-1 concentrations decreased significantly (p 
      <0.001), and ICAM-1, VCAM-1, and E-selectin concentrations decreased 
      significantly (p <0.01 for all), but C-reactive protein concentrations did not 
      change. MCP-1 and other marker concentrations did not change in the control 
      group. FMD increased significantly in the HRT group (p <0.001) but did not change 
      in the control group. Nitroglycerin-induced vasodilation did not change in either 
      group. In conclusion, transdermal HRT decreased MCP-1 and cell adhesion molecule 
      concentrations and improved endothelial function in postmenopausal women. 
      Transdermal HRT may exert an antiatherosclerotic effect by improving MCP-1 and 
      cell adhesion molecule expression and endothelial function.
FAU - Sumino, Hiroyuki
AU  - Sumino H
AD  - Department of Medicine and Biological Science, Gunma University Graduate School 
      of Medicine, Maebashi, Gunma, Japan. suminoh@med.gunma-u.ac.jp
FAU - Ichikawa, Shuichi
AU  - Ichikawa S
FAU - Ohyama, Yoshio
AU  - Ohyama Y
FAU - Takahashi, Takashi
AU  - Takahashi T
FAU - Saito, Yuichiro
AU  - Saito Y
FAU - Nakamura, Tetsuya
AU  - Nakamura T
FAU - Kanda, Tsugiyasu
AU  - Kanda T
FAU - Kurabayashi, Masahiko
AU  - Kurabayashi M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Administration, Cutaneous
MH  - Aged
MH  - Arteriosclerosis/prevention & control
MH  - Biomarkers/*analysis
MH  - Chemokine CCL2/*blood
MH  - Endothelium, Vascular/physiology
MH  - Female
MH  - *Hormone Replacement Therapy
MH  - Humans
MH  - Inflammation
MH  - Middle Aged
MH  - Postmenopause
MH  - Regional Blood Flow
MH  - Vasodilation
EDAT- 2005/06/28 09:00
MHDA- 2005/08/03 09:00
CRDT- 2005/06/28 09:00
PHST- 2004/10/25 00:00 [received]
PHST- 2005/02/22 00:00 [revised]
PHST- 2005/02/22 00:00 [accepted]
PHST- 2005/06/28 09:00 [pubmed]
PHST- 2005/08/03 09:00 [medline]
PHST- 2005/06/28 09:00 [entrez]
AID - S0002-9149(05)00600-4 [pii]
AID - 10.1016/j.amjcard.2005.02.059 [doi]
PST - ppublish
SO  - Am J Cardiol. 2005 Jul 1;96(1):148-53. doi: 10.1016/j.amjcard.2005.02.059.