PMID- 15982232
OWN - NLM
STAT- MEDLINE
DCOM- 20051025
LR  - 20050628
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 53
IP  - 1
DP  - 2005 Jul
TI  - Allergic contact dermatitis from natural rubber latex in atopic dermatitis and 
      the risk of later Type I allergy.
PG  - 46-51
AB  - The aims of the study were to assess whether contact dermatitis in children could 
      be due to a delayed hypersensitivity reaction to natural rubber latex (NRL) and 
      to define risk factors for later occurrence of Type I hypersensitivity to this 
      allergen. Among 1800 children investigated for contact dermatitis, 55 were 
      referred on suspicion of rubber allergy and had patch tests to NRL, as well as 
      prick tests and blood tests for specific immunoglobulin E (IgE). A 2-year 
      follow-up was then carried out. Delayed hypersensitivity to NRL was confirmed in 
      32 children. Patch testing with NRL proved to be positive, and clinical 
      improvement confirmed the diagnosis and relevance of patch tests. 30 of these 32 
      patients had associated atopic dermatitis (AD). Prick tests and blood tests for 
      specific IgE to latex were negative at the time of diagnosis. A 2-year follow-up 
      showed that 10 of 27 patients presenting initially with a positive patch test 
      without associated Type I sensitization later developed immediate 
      hypersensitivity. Children with AD are at high risk for allergy to NRL protein. 
      Exclusion of this allergen should be strongly advised in atopics because of the 
      dual risk of dermatitis and later evolution into severe Type I hypersensitivity.
FAU - Guillet, G
AU  - Guillet G
AD  - Department of Dermatology and Venereology, Centre Hospitalo-Universitaire de 
      Poitiers, Poitiers, France.
FAU - Guillet, M H
AU  - Guillet MH
FAU - Dagregorio, G
AU  - Dagregorio G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
RN  - 0 (Latex)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*adverse effects
MH  - Child
MH  - Child Welfare
MH  - Dermatitis, Allergic Contact/diagnosis/*etiology
MH  - Dermatitis, Atopic/diagnosis/*etiology
MH  - Follow-Up Studies
MH  - France
MH  - Humans
MH  - Hypersensitivity, Immediate/etiology
MH  - Immunoglobulin E/blood
MH  - Latex/*adverse effects
MH  - Latex Hypersensitivity/diagnosis/*etiology/prevention & control
MH  - Patch Tests
MH  - Risk Factors
EDAT- 2005/06/29 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/06/29 09:00
PHST- 2005/06/29 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/06/29 09:00 [entrez]
AID - COD634 [pii]
AID - 10.1111/j.0105-1873.2005.00634.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2005 Jul;53(1):46-51. doi: 10.1111/j.0105-1873.2005.00634.x.