PMID- 15982255
OWN - NLM
STAT- MEDLINE
DCOM- 20050923
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 66
IP  - 1
DP  - 2005 Jul
TI  - Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong 
      Han population in China.
PG  - 37-43
AB  - In the present study, polymerase chain reaction-sequence-based typing (PCR-SBT) 
      was used to analyze human leukocyte antigen (HLA)-DRB1, -DQB1, and -DPB1 alleles 
      of 98 unrelated healthy Shandong Han individuals. A total of 60 alleles, in which 
      28 in DRB1, 15 in DQB1 and 17 in DPB1 were found. Among the 28 detected DRB1 
      alleles, DRB1*150101, DRB1*070101, DRB1*090102, DRB1*120201, and DRB1*080302 were 
      commonly observed, with frequencies of 16.3%, 11.2%, 10.2%, 8.2%, and 5.6%, 
      respectively. The most predominant DQB1 allele was DQB1*030101/0309 with the 
      frequency of 20.4%, followed by DQB1*0201/0202 (14.8%), DQB1*0602 (14.3%), 
      DQB1*030302 (12.2%), and DQB1*060101/060103 (10.7%). Of the 17 detected DPB1 
      alleles, DPB1*0501 was the most frequent allele with the frequency of 37.2%. 
      DPB1*020102 (18.4%), DPB1*040101 (11.2%), DPB1*0402 (7.1%), and DPB1*1701 (6.6%) 
      were also very frequent alleles. A total of 53 estimated DRB1-DQB1 two-locus 
      haplotypes were observed in Shandong Han population, of which 
      DRB1*150101-DQB1*0602 was the most predominant, followed by 
      DRB1*090102-DQB1*030302, DRB1*070101-DQB1*0201/0202 DRB1*120201-DQB1*030101/0309, 
      and DRB1*080302- DQB1*060101/060103. The distribution of the HLA class II alleles 
      and haplotypes frequencies as well as the dendrogram showed that the Shandong Han 
      population belongs to the northern group of Chinese. The data have implications 
      for anthropological studies and disease associations.
FAU - Zhou, L
AU  - Zhou L
AD  - Key Laboratory of Genetic Engineering of Ministry of Education, Department of 
      Biochemistry, College of Life Sciences, Sun Yat-Sen (Zhongshan) University, 
      Guangzhou, People's Republic of China.
FAU - Lin, B
AU  - Lin B
FAU - Xie, Y
AU  - Xie Y
FAU - Liu, Z
AU  - Liu Z
FAU - Yan, W
AU  - Yan W
FAU - Xu, A
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People
MH  - China
MH  - Exons
MH  - Gene Frequency
MH  - HLA Antigens
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Phylogeny
MH  - *Polymorphism, Genetic
EDAT- 2005/06/29 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/29 09:00
PHST- 2005/06/29 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/29 09:00 [entrez]
AID - TAN418 [pii]
AID - 10.1111/j.1399-0039.2005.00418.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Jul;66(1):37-43. doi: 10.1111/j.1399-0039.2005.00418.x.