PMID- 15982494
OWN - NLM
STAT- MEDLINE
DCOM- 20051024
LR  - 20161124
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 102
IP  - 2
DP  - 2005 Jul 10
TI  - Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated 
      backscatter.
PG  - 259-68
AB  - BACKGROUND: It is not known whether cardiac markers and cyclic variations of 
      integrated backscatter can be used to detect cardiac sarcoidosis. METHODS: We 
      studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 
      patients with cardiac involvement and 35 patients without). The cyclic variation 
      of integrated backscatter and wall thickening was evaluated in the left 
      ventricular anterior septum and posterior wall. Plasma A-type natriuretic peptide 
      (ANP) and B-type natriuretic peptide (BNP) concentrations and serum cardiac 
      troponin T were also determined. RESULTS: Plasma natriuretic peptide 
      concentrations were higher in the cardiac involvement group (ANP: 15.5 
      [interquartile range (IQR) 2.5-34.0] vs. 12.0 [10.0-16.5] pg/ml, P=0.25; BNP: 
      28.6 [5.9-141] vs. 10.1 [4.8-15.4] pg/ml, P=0.049). However, cardiac troponin T 
      concentration was <0.01 ng/ml in all patients. Receiver-operator characteristic 
      (ROC) analysis showed that both ANP and BNP could identify patients with 
      high-degree atrioventricular block, ventricular tachyarrhythmias, or symptomatic 
      heart failure (the areas under the ROC curve were 0.94 and 0.97, respectively). 
      The cardiac involvement group could be distinguished from the noninvolvement 
      group by combining cutoff values for the magnitude of integrated backscatter 
      cyclic variation (5.5 dB) and wall thickening (30%), albeit only for the 
      posterior wall. CONCLUSION: Both ANP and BNP are useful markers for identifying 
      patients with sarcoidosis and cardiac complication(s). Moreover, evaluation of 
      integrated backscatter cyclic variation combined with wall thickening may be of 
      help in detecting cardiac involvement in the posterior wall.
FAU - Yasutake, Hiroko
AU  - Yasutake H
AD  - First Department of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 
      Tokyo 113-8603, Japan. nr6h-ystk@asahi-net.or.jp
FAU - Seino, Yoshihiko
AU  - Seino Y
FAU - Kashiwagi, Mutsumi
AU  - Kashiwagi M
FAU - Honma, Hiroshi
AU  - Honma H
FAU - Matsuzaki, Tsuyako
AU  - Matsuzaki T
FAU - Takano, Teruo
AU  - Takano T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Cardiomyopathies/blood/*diagnosis
MH  - *Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Gated Blood-Pool Imaging
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sarcoidosis/blood/*diagnosis
MH  - Severity of Illness Index
MH  - Troponin T/*blood
EDAT- 2005/06/29 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/06/29 09:00
PHST- 2003/12/24 00:00 [received]
PHST- 2004/04/12 00:00 [revised]
PHST- 2004/05/05 00:00 [accepted]
PHST- 2005/06/29 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/06/29 09:00 [entrez]
AID - S0167-5273(04)00490-5 [pii]
AID - 10.1016/j.ijcard.2004.05.028 [doi]
PST - ppublish
SO  - Int J Cardiol. 2005 Jul 10;102(2):259-68. doi: 10.1016/j.ijcard.2004.05.028.