PMID- 15982558
OWN - NLM
STAT- MEDLINE
DCOM- 20050922
LR  - 20050628
IS  - 0966-3274 (Print)
IS  - 0966-3274 (Linking)
VI  - 14
IP  - 3-4
DP  - 2005 Aug
TI  - Is the ABO incompatibility a risk factor in bone marrow transplantation?
PG  - 159-69
AB  - ABO histo-bloodgroups are strong transplantation antigens. In bone marrow 
      transplantation, foreign ABO red cell antigens are not ignored by the immune 
      system of the host, neither by the immunocompetent cells of the graft. Although 
      ABO incompatibility is not considered a contraindication in bone marrow 
      transplantation (BMT), its clinical consequences are still a matter of 
      investigation. An overview of reports published by different groups is given and 
      discussed. They present conflicting data regarding the role of the ABO match 
      between patient and donor in the haematopoietic stem cell (HSC) transplantation. 
      We report on the clinical outcome of bone marrow transplantation in 223 patients 
      who received grafts from MHC identical siblings. Included are 139 ABO identical, 
      32 ABO minor mismatched, 34 major mismatched and 13 bi-directionally mismatched 
      pairs. The statistical evaluation of standard parameters used to monitor the 
      post-transplant period gave a proof that in neither group of patients with an ABO 
      incompatible donor the recovery and success rate of transplantation, including 
      the relapse incidence, risk of graft vs. host disease (GVHD) or overall survival, 
      were significantly inferior. However, in all three cohorts of ABO mismatched 
      patients, a delayed recovery of neutrophils was recorded as compared to the group 
      receiving an ABO compatible graft. These finding leads us to the conclusion that 
      the ABO compatibility is not a disadvantage in BMT, whereas the delayed recovery 
      of neutrophils in patients having received an ABO mismatched graft is probably 
      reflecting a transient humoral process leading to immune tolerance and graft 
      accommodation.
FAU - Rozman, Primoz
AU  - Rozman P
AD  - Blood Transfusion Centre of Slovenia, Department of Immunohematology, Slajmerjeva 
      6, SI-1000 Ljubljana, Slovenia. primoz.rozman@ztm.si
FAU - Kosir, Andrej
AU  - Kosir A
FAU - Bohinjec, Mateja
AU  - Bohinjec M
LA  - eng
PT  - Journal Article
DEP - 20050426
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Adult
MH  - *Blood Group Incompatibility
MH  - Bone Marrow Transplantation/*immunology
MH  - Female
MH  - Graft Survival/immunology
MH  - Graft vs Host Disease/epidemiology
MH  - Humans
MH  - Male
MH  - Neutrophils/immunology
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2005/06/29 09:00
MHDA- 2005/09/24 09:00
CRDT- 2005/06/29 09:00
PHST- 2005/03/14 00:00 [accepted]
PHST- 2005/06/29 09:00 [pubmed]
PHST- 2005/09/24 09:00 [medline]
PHST- 2005/06/29 09:00 [entrez]
AID - S0966-3274(05)00031-6 [pii]
AID - 10.1016/j.trim.2005.03.005 [doi]
PST - ppublish
SO  - Transpl Immunol. 2005 Aug;14(3-4):159-69. doi: 10.1016/j.trim.2005.03.005. Epub 
      2005 Apr 26.