PMID- 15983169
OWN - NLM
STAT- MEDLINE
DCOM- 20050816
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 60
IP  - 6
DP  - 2005 Jun
TI  - Caloric restriction decreases survival of aged mice in response to primary 
      influenza infection.
PG  - 688-94
AB  - Caloric restriction (CR) extends life span of healthy rodents compared to those 
      fed ad libitum. Previous studies have shown positive effects of CR on the immune 
      response of aged mice after influenza immunization. To extend these studies, a 
      mouse model of CR was used to determine if CR could modulate primary responses of 
      aged mice to influenza. Although CR delayed the age-related decrease in 
      mitogen-induced lymphoproliferation of aged mice, in stark contrast, CR decreased 
      survival, increased virus titers, and reduced natural killer cell activity in 
      lungs of aged mice after primary influenza infection. Thus, CR has differential 
      effects on immunity of aged mice, as general indices of immune response are 
      maintained, but primary responses to influenza infection are impaired. This 
      suggests that, although CR may positively affect many long-term parameters of 
      aging, increased susceptibility after primary exposure of aged mice to virus, 
      such as influenza, may not be correctable by CR.
FAU - Gardner, Elizabeth M
AU  - Gardner EM
AD  - Drexel University, Department of Bioscience and Biotechnology, 3141 Chestnut 
      Street, Philadelphia, PA 19104, USA. eg25@drexel.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Influenza A virus/isolation & purification
MH  - Killer Cells, Natural/immunology
MH  - Lung/virology
MH  - Male
MH  - Mice
MH  - Orthomyxoviridae Infections/*immunology/*mortality
MH  - Weight Loss/physiology
EDAT- 2005/06/29 09:00
MHDA- 2005/08/17 09:00
CRDT- 2005/06/29 09:00
PHST- 2005/06/29 09:00 [pubmed]
PHST- 2005/08/17 09:00 [medline]
PHST- 2005/06/29 09:00 [entrez]
AID - 60/6/688 [pii]
AID - 10.1093/gerona/60.6.688 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2005 Jun;60(6):688-94. doi: 
      10.1093/gerona/60.6.688.