PMID- 15985473
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20140729
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 90
IP  - 9
DP  - 2005 Sep
TI  - Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic 
      susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs.
PG  - 5104-9
AB  - CONTEXT: Human leukocyte antigen (HLA) class II genes contribute to the genetic 
      susceptibility of type 1 diabetes (T1D), and both susceptible and protective 
      alleles were implicated with its pathogenesis, which varies among various 
      ethnic/racial groups. OBJECTIVE: This study investigated the heterogeneity in HLA 
      class II haplotypes distribution among Bahraini and Lebanese T1D patients. 
      DESIGN: This was a cross-sectional retrospective study. SETTING: The study was 
      conducted at primary care private and public health centers. PATIENTS AND OTHER 
      PARTICIPANTS: Subjects comprised 126 T1D patients and 126 healthy controls from 
      Bahrain and 78 Lebanese T1D patients and 111 control subjects. INTERVENTION(S): 
      There were no interventions. RESULTS: Although Lebanese and Bahraini patients 
      share DRB1*030101, DQB1*0201 as susceptible and DRB1*100101 and DQB1*030101 as 
      protective alleles, DRB1*040101 was an additional susceptible allele in Bahraini 
      patients, and DRB1*130701 and DQB1*050101 were additional susceptible and 
      protective alleles in Lebanese, respectively. DRB1*030101-DQB1*0201 was 
      susceptible, whereas DRB1*070101-DQB1*0201 and DRB1*110101-DQB1*030101 were 
      protective haplotypes in Bahraini and Lebanese. DRB1*040101-DQB1*0302 and 
      DRB1*040101-DQB1*050101 displayed different associations: they were protective in 
      Lebanese but susceptible or neutral among Bahrainis. Whereas the frequency of 
      homozygous DRB1*03011-DQB1*0201 was higher in Bahraini and to a lesser extent 
      Lebanese patients, homozygous DRB1*110101-DQB1*030101 was significantly more 
      frequent in Lebanese but not Bahraini controls, whereas 
      DRB1*030101-DQB1*0201/DRB1*040101-DQB1*0201 was the major genotype among Bahraini 
      patients but not Lebanese subjects in whom it was present at very low 
      frequencies. CONCLUSION: In view of these differences between Bahraini and 
      Lebanese, this demonstrates that the contribution of HLA class II to the genetic 
      susceptibility to T1D must be evaluated with regard to specific HLA haplotypes 
      and also ethnic origin and racial background.
FAU - Al-Jenaidi, Fayza A
AU  - Al-Jenaidi FA
AD  - Al-Jawhara Center for Molecular Medicine, Genetics, and Inherited Diseases, 
      College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 
      22979, Manama, Bahrain.
FAU - Wakim-Ghorayeb, Saria F
AU  - Wakim-Ghorayeb SF
FAU - Al-Abbasi, Abduljabbar
AU  - Al-Abbasi A
FAU - Arekat, Mona R
AU  - Arekat MR
FAU - Irani-Hakime, Noha
AU  - Irani-Hakime N
FAU - Najm, Pierre
AU  - Najm P
FAU - Al-Ola, Khadija
AU  - Al-Ola K
FAU - Motala, Ayesha A
AU  - Motala AA
FAU - Almawi, Wassim Y
AU  - Almawi WY
LA  - eng
PT  - Journal Article
DEP - 20050628
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*11:01:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Arabs/*genetics
MH  - Bahrain
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Lebanon
MH  - Male
MH  - Retrospective Studies
EDAT- 2005/06/30 09:00
MHDA- 2005/10/07 09:00
CRDT- 2005/06/30 09:00
PHST- 2005/06/30 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2005/06/30 09:00 [entrez]
AID - jc.2005-1166 [pii]
AID - 10.1210/jc.2005-1166 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2005 Sep;90(9):5104-9. doi: 10.1210/jc.2005-1166. Epub 
      2005 Jun 28.