PMID- 15989466
OWN - NLM
STAT- MEDLINE
DCOM- 20050831
LR  - 20071115
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 21
IP  - 6
DP  - 2005 Jun
TI  - Sequences of clustered epitopes in Gag and Nef potentially presented by 
      predominant class I human leukocyte antigen (HLA) alleles A and B expressed by 
      human immunodeficiency virus type 1 (HIV-1)-infected patients in Vietnam.
PG  - 586-91
AB  - The aim of this study was to define pluriepitopic regions in Gag and Nef possibly 
      relevant in the perspective of a vaccine design in a vietnamese population. The 
      protein sequences derived from gag and nef genes and phenotyping of the class I 
      human leukocyte antigens (HLA) A and B alleles were established for 28 human 
      immunodeficiency virus type 1 (HIV-1)-infected patients from Ho Chi Minh City, 
      Vietnam. The protein sequences display polymorphism mutations as compared with a 
      B reference strain (HXB2). The most frequently represented HLA-A and -B alleles 
      were HLA-A11, A02, and A33 expressed by 35.7, 23.2, and 21.4% of the patients, 
      respectively, and HLA-B75, B46, and B62 expressed by 35.7, 25, and 17.9% of the 
      patients, respectively. This study allows us to determine four pluriepitopic 
      regions in Gag and Nef that should be chosen for a vaccine design in a Vietnamese 
      population.
FAU - Lazaro, Estibaliz
AU  - Lazaro E
AD  - Laboratoire de Virologie (EA 2968), Universite Victor Segalen-Bordeaux 2, 
      Bordeaux, France.
FAU - Theodorou, Ioannis
AU  - Theodorou I
FAU - Legrand, Elisabeth
AU  - Legrand E
FAU - Recordon-Pinson, Patricia
AU  - Recordon-Pinson P
FAU - Boucher, Sebastien
AU  - Boucher S
FAU - Capoulade, Corinne
AU  - Capoulade C
FAU - Lan, Thi Hoang
AU  - Lan TH
FAU - Hung, Pham Van
AU  - Hung PV
FAU - Debre, Patrice
AU  - Debre P
FAU - Fleury, Herve
AU  - Fleury H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (AIDS Vaccines)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Gene Products, gag)
RN  - 0 (Gene Products, nef)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - AIDS Vaccines
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Drug Design
MH  - *Epitopes, T-Lymphocyte/chemistry/immunology
MH  - *Gene Products, gag/chemistry/genetics/immunology
MH  - *Gene Products, nef/chemistry/genetics/immunology
MH  - HIV Infections/immunology/virology
MH  - HIV-1
MH  - HLA-A Antigens/genetics/*immunology/metabolism
MH  - HLA-B Antigens/genetics/*immunology/metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - Vietnam
MH  - nef Gene Products, Human Immunodeficiency Virus
EDAT- 2005/07/02 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/07/02 09:00
PHST- 2005/07/02 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/07/02 09:00 [entrez]
AID - 10.1089/aid.2005.21.586 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2005 Jun;21(6):586-91. doi: 10.1089/aid.2005.21.586.